Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 During Pathogenesis

Overview

Journal Cancer Res

Specialty Oncology

Date 2022 Oct 7

PMID 36206311

Authors

Yeh Wang

Peng Huang

Brant G Wang

Tricia Murdock

Leslie Cope

Fang-Chi Hsu

Tian-Li Wang

Ie-Ming Shih

Affiliations

Soon will be listed here.

Abstract

Significance: Molecular studies of the earliest precursor lesions of ovarian cancer reveal a role of IGFBP2 in propelling tumor initiation, providing new insights into ovarian cancer development.

Citing Articles

A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause.

Weigert M, Li Y, Zhu L, Eckart H, Bajwa P, Krishnan R Nat Commun. 2025; 16(1):372.

PMID: 39753552 PMC: 11698969. DOI: 10.1038/s41467-024-55440-2.

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer.

Haanen 3rd T, Haanen T, Boock S, Callahan C, Peris I, Zawacki K Cancer Res. 2024; 85(3):442-461.

PMID: 39531506 PMC: 11788061. DOI: 10.1158/0008-5472.CAN-24-1263.

Prognostic modeling and Emerging therapeutic targets Unveiled through single-cell sequencing in esophageal squamous Cell carcinoma.

Pan B, Shi H, Shan G, Wu G, Rao K, Liang J Heliyon. 2024; 10(19):e38078.

PMID: 39397956 PMC: 11470424. DOI: 10.1016/j.heliyon.2024.e38078.

Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube.

Crawford A, Forjaz A, Bons J, Bhorkar I, Roy T, Schell D Sci Adv. 2024; 10(39):eadp6285.

PMID: 39331707 PMC: 11430475. DOI: 10.1126/sciadv.adp6285.

Alicea G, Patel P, Portuallo M, Fane M, Wei M, Chhabra Y Cancer Res Commun. 2024; 4(8):1908-1918.

PMID: 39007351 PMC: 11295880. DOI: 10.1158/2767-9764.CRC-23-0176.

References

Lee E, Mircean C, Shmulevich I, Wang H, Liu J, Niemisto A . Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion. Mol Cancer. 2005; 4(1):7. PMC: 549074. DOI: 10.1186/1476-4598-4-7. View

Epping M, Wang L, Edel M, Carlee L, Hernandez M, Bernards R . The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell. 2005; 122(6):835-47. DOI: 10.1016/j.cell.2005.07.003. View

Li Y, Jiang T, Zhang J, Zhang B, Yang W, You G . Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies. Ann Oncol. 2012; 23(9):2415-2422. DOI: 10.1093/annonc/mds007. View

Pisanic 2nd T, Wang Y, Sun H, Considine M, Li L, Wang T . Methylomic Landscapes of Ovarian Cancer Precursor Lesions. Clin Cancer Res. 2020; 26(23):6310-6320. PMC: 7710556. DOI: 10.1158/1078-0432.CCR-20-0270. View

Kuhn E, Kurman R, Vang R, Sehdev A, Han G, Soslow R . TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma--evidence supporting the clonal relationship of the two lesions. J Pathol. 2011; 226(3):421-6. PMC: 4782784. DOI: 10.1002/path.3023. View

Chatterjee A, Rodger E, Ahn A, Stockwell P, Parry M, Motwani J . Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma. iScience. 2018; 4:312-325. PMC: 6147024. DOI: 10.1016/j.isci.2018.05.021. View

Zhang W, Barger C, Eng K, Klinkebiel D, Link P, Omilian A . PRAME expression and promoter hypomethylation in epithelial ovarian cancer. Oncotarget. 2016; 7(29):45352-45369. PMC: 5216727. DOI: 10.18632/oncotarget.9977. View

Chu T, Shih I . Follicular fluid has more to offer: Insulin-like growth factor axis on ovarian carcinogenesis. EBioMedicine. 2019; 41:30-31. PMC: 6442987. DOI: 10.1016/j.ebiom.2019.02.030. View

So A, Levitt R, Eigl B, Fazli L, Muramaki M, Leung S . Insulin-like growth factor binding protein-2 is a novel therapeutic target associated with breast cancer. Clin Cancer Res. 2008; 14(21):6944-54. DOI: 10.1158/1078-0432.CCR-08-0408. View

10.

Liu D, Buluwela L, Ali S, Thomson S, Gomm J, Coombes R . Retroviral infection of the FGF2 gene into MCF-7 cells induces branching morphogenesis, retards cell growth and suppresses tumorigenicity in nude mice. Eur J Cancer. 2001; 37(2):268-80. DOI: 10.1016/s0959-8049(00)00392-0. View

11.

Haschemi R, Kobelt D, Steinwarz E, Schlesinger M, Stein U, Bendas G . Insulin-like Growth Factor Binding Protein-2 (IGFBP2) Is a Key Molecule in the MACC1-Mediated Platelet Communication and Metastasis of Colorectal Cancer Cells. Int J Mol Sci. 2021; 22(22). PMC: 8624049. DOI: 10.3390/ijms222212195. View

12.

Patil S, Gokulnath P, Bashir M, Shwetha S, Jaiswal J, Shastry A . Insulin-like growth factor binding protein-2 regulates β-catenin signaling pathway in glioma cells and contributes to poor patient prognosis. Neuro Oncol. 2016; 18(11):1487-1497. PMC: 5063512. DOI: 10.1093/neuonc/now053. View

13.

Huang H, Chu S, Hsu C, Chen P, Ding D, Chang M . Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis. Carcinogenesis. 2015; 36(11):1419-28. DOI: 10.1093/carcin/bgv132. View

14.

Kindelberger D, Lee Y, Miron A, Hirsch M, Feltmate C, Medeiros F . Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol. 2007; 31(2):161-9. DOI: 10.1097/01.pas.0000213335.40358.47. View

15.

Bahar-Shany K, Brand H, Sapoznik S, Jacob-Hirsch J, Yung Y, Korach J . Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma. Gynecol Oncol. 2013; 132(2):322-7. DOI: 10.1016/j.ygyno.2013.12.015. View

16.

Zhang Y, Ying X, Han S, Wang J, Zhou X, Bai E . Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer. Int J Oncol. 2012; 42(1):93-100. PMC: 3583617. DOI: 10.3892/ijo.2012.1699. View

17.

Bell R, Golan T, Sheinboim D, Malcov H, Amar D, Salamon A . Enhancer methylation dynamics contribute to cancer plasticity and patient mortality. Genome Res. 2016; 26(5):601-11. PMC: 4864467. DOI: 10.1101/gr.197194.115. View

18.

Ducie J, Dao F, Considine M, Olvera N, Shaw P, Kurman R . Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma. Nat Commun. 2017; 8(1):990. PMC: 5645359. DOI: 10.1038/s41467-017-01217-9. View

19.

Liu Y, Nelson M, Bailey C, Zhang P, Zheng P, Dome J . Targeting the HIF-1α-IGFBP2 axis therapeutically reduces IGF1-AKT signaling and blocks the growth and metastasis of relapsed anaplastic Wilms tumor. Oncogene. 2021; 40(29):4809-4819. PMC: 8319145. DOI: 10.1038/s41388-021-01907-1. View

20.

Perks C, Vernon E, Rosendahl A, Tonge D, Holly J . IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells. Oncogene. 2007; 26(40):5966-72. DOI: 10.1038/sj.onc.1210397. View