» Articles » PMID: 3620547

Optimization by Stimulating Molecular Evolution

Overview
Journal Biol Cybern
Specialties Neurology
Physiology
Date 1987 Jan 1
PMID 3620547
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

Based on the analogy between mathematical optimization and molecular evolution and on Eigen's quasi-species model of molecular evolution, an evolutionary algorithm for combinatorial optimization has been developed. This algorithm consists of a versatile variation scheme and an innovative decision rule, the essence of which lies in a radical revision of the conventional philosophy of optimization: A number of configurations of variables with better values, instead of only a single best configuration, are selected as starting points for the next iteration. As a result the search proceeds in parallel along a number of routes and is unlikely to get trapped in local optima. An important innovation of the algorithm is introduction of a constraint to let the starting points always keep a certain distance from each other so that the search is able to cover a larger region of space effectively. The main advantage of the algorithm is that it has more chances to find the global optimum and as many local optima as possible in a single run. This has been demonstrated in preliminary computational experiments.

Citing Articles

Optimization by hierarchical mutant production.

Schober A, Thuerk M, Eigen M Biol Cybern. 1993; 69(5-6):493-501.

PMID: 8274548


RNA based evolutionary optimization.

Schuster P Orig Life Evol Biosph. 1993; 23(5-6):373-91.

PMID: 7509478 DOI: 10.1007/BF01582087.

References
1.
Eigen M, Schuster P . The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle. Naturwissenschaften. 1977; 64(11):541-65. DOI: 10.1007/BF00450633. View

2.
Kramer F, Mills D, Cole P, Nishihara T, Spiegelman S . Evolution in vitro: sequence and phenotype of a mutant RNA resistant to ethidium bromide. J Mol Biol. 1974; 89(4):719-36. DOI: 10.1016/0022-2836(74)90047-3. View

3.
Hopfield J . Neural networks and physical systems with emergent collective computational abilities. Proc Natl Acad Sci U S A. 1982; 79(8):2554-8. PMC: 346238. DOI: 10.1073/pnas.79.8.2554. View

4.
Spiegelman S . The development and use of an extracellular RNA replicating system. Harvey Lect. 1968; 64:1-67. View

5.
Biebricher C, Eigen M, Luce R . Kinetic analysis of template-instructed and de novo RNA synthesis by Q beta replicase. J Mol Biol. 1981; 148(4):391-410. DOI: 10.1016/0022-2836(81)90183-2. View