Mitochondrial Dysfunction in Microglia: a Novel Perspective for Pathogenesis of Alzheimer's Disease

Overview

Journal J Neuroinflammation

Publisher Biomed Central

Date 2022 Oct 6

PMID 36203194

Authors

Yun Li

Xiaohuan Xia

Yi Wang

Jialin C Zheng

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key contributor to the onset and progression of AD, however, the mechanisms that mediate neuroinflammation remain largely unknown. Recent studies have suggested mitochondrial dysfunction including mitochondrial DNA (mtDNA) damage, metabolic defects, and quality control (QC) disorders precedes microglial activation and subsequent neuroinflammation. Therefore, an in-depth understanding of the relationship between mitochondrial dysfunction and microglial activation in AD is important to unveil the pathogenesis of AD and develop effective approaches for early AD diagnosis and treatment. In this review, we summarized current progress in the roles of mtDNA, mitochondrial metabolism, mitochondrial QC changes in microglial activation in AD, and provide comprehensive thoughts for targeting microglial mitochondria as potential therapeutic strategies of AD.

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