Lack of Inhibitory Effect of Metronidazole on Theophylline Disposition in Healthy Subjects

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1987 Jul 1

PMID 3620280

Citations 4

Authors

G I Adebayo

A F Mabadeje

Affiliations

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Abstract

The effect of metronidazole, at a dose of 1.2 g daily, on theophylline disposition was studied in 10 healthy adult volunteers. Neither theophylline half-life, volume of distribution nor total body clearance was altered by the anti-microbial. It is concluded that metronidazole does not impair theophylline metabolism despite the fact that it is a substituted imidazole.

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