Building an Integrated Serosurveillance Platform to Inform Public Health Interventions: Insights from an Experts' Meeting on Serum Biomarkers

Overview

Journal PLoS Negl Trop Dis

Specialties Infectious Diseases
Tropical Medicine

Date 2022 Oct 6

PMID 36201428

Authors

Kirsten E Wiens

Barbara Jauregui

Benjamin F Arnold

Kathryn Banke

Djibril Wade

Kyla Hayford

Adriana Costero-Saint Denis

Robert H Hall

Henrik Salje

Isabel Rodriguez-Barraquer

Andrew S Azman

Guy Vernet

Daniel T Leung

Affiliations

Soon will be listed here.

Abstract

The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public health program design and response to infectious threats. In July 2018, 70 scientists from 16 countries met to perform a landscape analysis of approaches that support an integrated serosurveillance platform, including the consideration of issues for successful implementation. Here, we summarize the group's insights and proposed roadmap for implementation, including objectives, technical requirements, ethical issues, logistical considerations, and monitoring and evaluation.

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References

Le Vu S, Pillonel J, Semaille C, Bernillon P, Le Strat Y, Meyer L . Principles and uses of HIV incidence estimation from recent infection testing--a review. Euro Surveill. 2008; 13(36). View

Martin D, Saboya-Diaz M, Abashawl A, Alemayeh W, Gwyn S, Hooper P . The use of serology for trachoma surveillance: Current status and priorities for future investigation. PLoS Negl Trop Dis. 2020; 14(9):e0008316. PMC: 7514076. DOI: 10.1371/journal.pntd.0008316. View

Swart E, van Gageldonk P, de Melker H, van der Klis F, Berbers G, Mollema L . Long-Term Protection against Diphtheria in the Netherlands after 50 Years of Vaccination: Results from a Seroepidemiological Study. PLoS One. 2016; 11(2):e0148605. PMC: 4749226. DOI: 10.1371/journal.pone.0148605. View

Salje H, Cauchemez S, Alera M, Rodriguez-Barraquer I, Thaisomboonsuk B, Srikiatkhachorn A . Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission. J Infect Dis. 2015; 213(4):604-10. PMC: 4721913. DOI: 10.1093/infdis/jiv470. View

Pisanic N, Randad P, Kruczynski K, Manabe Y, Thomas D, Pekosz A . COVID-19 Serology at Population Scale: SARS-CoV-2-Specific Antibody Responses in Saliva. J Clin Microbiol. 2020; 59(1). PMC: 7771435. DOI: 10.1128/JCM.02204-20. View

Wilking H, Thamm M, Stark K, Aebischer T, Seeber F . Prevalence, incidence estimations, and risk factors of Toxoplasma gondii infection in Germany: a representative, cross-sectional, serological study. Sci Rep. 2016; 6:22551. PMC: 4776094. DOI: 10.1038/srep22551. View

Cherry J, Gornbein J, Heininger U, Stehr K . A search for serologic correlates of immunity to Bordetella pertussis cough illnesses. Vaccine. 1998; 16(20):1901-6. DOI: 10.1016/s0264-410x(98)00226-6. View

Flamand C, Bailly S, Fritzell C, Berthelot L, Vanhomwegen J, Salje H . Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey. J Infect Dis. 2019; 220(12):1915-1925. PMC: 6834069. DOI: 10.1093/infdis/jiz396. View

Abimbola S, Asthana S, Montenegro C, Guinto R, Jumbam D, Louskieter L . Addressing power asymmetries in global health: Imperatives in the wake of the COVID-19 pandemic. PLoS Med. 2021; 18(4):e1003604. PMC: 8101997. DOI: 10.1371/journal.pmed.1003604. View

10.

Mbaye E, Kone S, Ka O, Mboup S . [Evolution of Community engagement in the fight against Ebola]. Sante Publique. 2017; 29(4):487-496. DOI: 10.3917/spub.174.0487. View

11.

Woodhall S, Gorwitz R, Migchelsen S, Gottlieb S, Horner P, Geisler W . Advancing the public health applications of Chlamydia trachomatis serology. Lancet Infect Dis. 2018; 18(12):e399-e407. PMC: 6414067. DOI: 10.1016/S1473-3099(18)30159-2. View

12.

Greenhouse B, Smith D, Rodriguez-Barraquer I, Mueller I, Drakeley C . Taking Sharper Pictures of Malaria with CAMERAs: Combined Antibodies to Measure Exposure Recency Assays. Am J Trop Med Hyg. 2018; 99(5):1120-1127. PMC: 6221205. DOI: 10.4269/ajtmh.18-0303. View

13.

Azman A, Lessler J, Luquero F, Bhuiyan T, Khan A, Chowdhury F . Estimating cholera incidence with cross-sectional serology. Sci Transl Med. 2019; 11(480). PMC: 6430585. DOI: 10.1126/scitranslmed.aau6242. View

14.

Drame P, Poinsignon A, Besnard P, Le Mire J, Dos-Santos M, Sow C . Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control. Am J Trop Med Hyg. 2010; 83(1):115-21. PMC: 2912587. DOI: 10.4269/ajtmh.2010.09-0684. View

15.

Doucoure S, Mouchet F, Cournil A, Le Goff G, Cornelie S, Roca Y . Human antibody response to Aedes aegypti saliva in an urban population in Bolivia: a new biomarker of exposure to Dengue vector bites. Am J Trop Med Hyg. 2012; 87(3):504-10. PMC: 3435356. DOI: 10.4269/ajtmh.2012.11-0477. View

16.

Azman A, Lauer S, Bhuiyan T, Luquero F, Leung D, Hegde S . O1 transmission in Bangladesh: insights from a nationally representative serosurvey. Lancet Microbe. 2020; 1(8):e336-e343. PMC: 7738617. DOI: 10.1016/S2666-5247(20)30141-5. View

17.

Priest J, Moss D, Arnold B, Hamlin K, Jones C, Lammie P . Seroepidemiology of Toxoplasma in a coastal region of Haiti: multiplex bead assay detection of immunoglobulin G antibodies that recognize the SAG2A antigen. Epidemiol Infect. 2015; 143(3):618-30. PMC: 5844480. DOI: 10.1017/S0950268814001216. View

18.

Harris J, LaRocque R, Chowdhury F, Khan A, Logvinenko T, Faruque A . Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh. PLoS Negl Trop Dis. 2008; 2(4):e221. PMC: 2271133. DOI: 10.1371/journal.pntd.0000221. View

19.

Scobie H, Mao B, Buth S, Wannemuehler K, Sorensen C, Kannarath C . Tetanus Immunity among Women Aged 15 to 39 Years in Cambodia: a National Population-Based Serosurvey, 2012. Clin Vaccine Immunol. 2016; 23(7):546-54. PMC: 4933773. DOI: 10.1128/CVI.00052-16. View

20.

Bryant J, Azman A, Ferrari M, Arnold B, Boni M, Boum Y . Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward. Sci Immunol. 2020; 5(47). DOI: 10.1126/sciimmunol.abc6347. View