Characteristics of the Gut Microbiota in Japanese Patients with Premenstrual Syndrome

Overview

Journal Int J Womens Health

Publisher Dove Medical Press

Specialty Gynecology & Obstetrics

Date 2022 Oct 6

PMID 36199913

Authors

Kana Okuma

Kanako Kono

Machiko Otaka

Aya Ebara

Ayano Odachi

Hidetaka Tokuno

Hiroaki Masuyama

Affiliations

Soon will be listed here.

Abstract

Purpose: The present study aimed to characterize the gut microbiota of individuals with premenstrual syndrome.

Patients And Methods: The gut microbiota of 24 Japanese women with PMS (PMS group) and 144 healthy Japanese women (control group) were compared. Analysis of the α- and β-diversities and the gut microbial composition at the genus level were performed using 16S rRNA gene sequence data obtained from stool samples.

Results: A significant difference in age was observed between the PMS and control groups; however, no significant difference was observed in BMI. The α-diversity measured using the Simpson index was significantly higher in the PMS group than the control group. Visualization of the β-diversity using non-metric multidimensional scaling and permutational multivariate analysis of variance (PERMANOVA) showed that the distance of the gut microbiota between the PMS and control groups is significantly different. Furthermore, a significant difference in the composition of the gut microbiota was observed between the PMS and control groups. At the genus level, the abundances of , and were significantly higher in the PMS group than in the control group. In particular, the abundance of in the PMS group was approximately 4.5 times higher than that in the control group. To rule out the confounding effect of age in the abundances of , and , the gut microbiota of the PMS and control groups were compared by age group. Results showed that had the highest effect size in participants of 30-40 years of age (mean age: 36.39 ± 4.68 years).

Conclusion: These results suggest that the PMS group possesses a characteristic gut microbiota. In particular, was strongly associated with PMS. Since has been reported to be associated with diet, dietary interventions such as prebiotics targeting may be effective in preventing, improving, and alleviating PMS.

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