The Incidence and Risk Factors of Renal Insufficiency Among Korean HIV Infected Patients: The Korea HIV/AIDS Cohort Study

Overview

Journal Infect Chemother

Specialty Infectious Diseases

Date 2022 Oct 5

PMID 36196611

Authors

Jun Hyoung Kim

Heeseon Jang

Jung Ho Kim

Joon Young Song

Shin-Woo Kim

Sang Il Kim

Bo Youl Choi

Jun Yong Choi

Affiliations

Soon will be listed here.

Abstract

Renal insufficiency is one of the common issues in people living with human immunodeficiency virus (PLHIV). We studied the incidence and risk factors for renal insufficiency in male PLHIV using the Korea HIV/acquired immunodeficiency syndrome (AIDS) Cohort Study. Among the 830 enrolled patients, 32 (3.9%) cases of renal insufficiency occurred over 9576 patient-years of follow-up. The incidence of renal insufficiency in HIV-infected men in this study was 3.3 per 1000 patient-years. Diabetes mellitus, dyslipidemia, tenofovir or non-nucleoside reverse transcriptase inhibitor exposure for >1 year, and AIDS-defining illness were risk factors for renal insufficiency.

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References

. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015. Lancet HIV. 2016; 3(8):e361-e387. PMC: 5056319. DOI: 10.1016/S2352-3018(16)30087-X. View

Cheung J, Puhr R, Petoumenos K, Cooper D, Woolley I, Gunathilake M . Chronic kidney disease in Australian Human Immunodeficiency Virus-infected patients: Analysis of the Australian HIV Observational Database. Nephrology (Carlton). 2017; 23(8):778-786. PMC: 5799037. DOI: 10.1111/nep.13100. View

Choi B, Choi J, Han S, Kim S, Kee M, Kim M . Korea HIV/AIDS Cohort Study: study design and baseline characteristics. Epidemiol Health. 2018; 40:e2018023. PMC: 6178365. DOI: 10.4178/epih.e2018023. View

Boender T, Smit C, van Sighem A, Bezemer D, Ester C, Zaheri S . AIDS Therapy Evaluation in the Netherlands (ATHENA) national observational HIV cohort: cohort profile. BMJ Open. 2018; 8(9):e022516. PMC: 6169757. DOI: 10.1136/bmjopen-2018-022516. View

Suzuki S, Nishijima T, Kawasaki Y, Kurosawa T, Mutoh Y, Kikuchi Y . Effect of Tenofovir Disoproxil Fumarate on Incidence of Chronic Kidney Disease and Rate of Estimated Glomerular Filtration Rate Decrement in HIV-1-Infected Treatment-Naïve Asian Patients: Results from 12-Year Observational Cohort. AIDS Patient Care STDS. 2017; 31(3):105-112. PMC: 5359640. DOI: 10.1089/apc.2016.0286. View

Chang H . Weight Gain and Metabolic Syndrome in Human Immunodeficiency Virus Patients. Infect Chemother. 2022; 54(2):220-235. PMC: 9259920. DOI: 10.3947/ic.2022.0061. View

Tourret J, Deray G, Isnard-Bagnis C . Tenofovir effect on the kidneys of HIV-infected patients: a double-edged sword?. J Am Soc Nephrol. 2013; 24(10):1519-27. PMC: 3785270. DOI: 10.1681/ASN.2012080857. View

Lee M, Ha K, Kim D, Park I . Trends in the Incidence, Prevalence, and Mortality of End-Stage Kidney Disease in South Korea. Diabetes Metab J. 2021; 44(6):933-937. PMC: 7801765. DOI: 10.4093/dmj.2020.0156. View

Pelchen-Matthews A, Ryom L, Borges A, Edwards S, Duvivier C, Stephan C . Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort. AIDS. 2018; 32(16):2405-2416. DOI: 10.1097/QAD.0000000000001967. View

10.

Kim E, Ahn J, Kim Y, Wie S, Park D, Song J . The Prevalence and Risk Factors of Renal Insufficiency among Korean HIV-Infected Patients: The Korea HIV/AIDS Cohort Study. Infect Chemother. 2017; 49(3):194-204. PMC: 5620386. DOI: 10.3947/ic.2017.49.3.194. View

11.

Cohen S, Kopp J, Kimmel P . Kidney Diseases Associated with Human Immunodeficiency Virus Infection. N Engl J Med. 2017; 377(24):2363-2374. DOI: 10.1056/NEJMra1508467. View

12.

Smith C, Ryom L, Weber R, Morlat P, Pradier C, Reiss P . Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet. 2014; 384(9939):241-8. DOI: 10.1016/S0140-6736(14)60604-8. View

13.

Joshi K, Boettiger D, Kerr S, Nishijima T, Van Nguyen K, Ly P . Changes in renal function with long-term exposure to antiretroviral therapy in HIV-infected adults in Asia. Pharmacoepidemiol Drug Saf. 2018; 27(11):1209-1216. PMC: 6218305. DOI: 10.1002/pds.4657. View

14.

Shi R, Chen X, Lin H, Ding Y, He N . Incidence of impaired kidney function among people with HIV: a systematic review and meta-analysis. BMC Nephrol. 2022; 23(1):107. PMC: 8932163. DOI: 10.1186/s12882-022-02721-x. View

15.

Cho Y, Chin B . Assessment of Human Immunodeficiency Virus Care Continuum in Korea using the National Health Insurance System Data. Infect Chemother. 2021; 53(3):477-488. PMC: 8511369. DOI: 10.3947/ic.2021.0025. View

16.

Gupta S, Post F, Arribas J, Eron Jr J, Wohl D, Clarke A . Renal safety of tenofovir alafenamide vs. tenofovir disoproxil fumarate: a pooled analysis of 26 clinical trials. AIDS. 2019; 33(9):1455-1465. PMC: 6635043. DOI: 10.1097/QAD.0000000000002223. View

17.

Quesada P, Lopez Esteban L, Garcia J, Vazquez Sanchez R, Molina Garcia T, Alonso-Vega G . Incidence and risk factors for tenofovir-associated renal toxicity in HIV-infected patients. Int J Clin Pharm. 2015; 37(5):865-72. DOI: 10.1007/s11096-015-0132-1. View

18.

Abraham A, Althoff K, Jing Y, Estrella M, Kitahata M, Wester C . End-stage renal disease among HIV-infected adults in North America. Clin Infect Dis. 2014; 60(6):941-9. PMC: 4357817. DOI: 10.1093/cid/ciu919. View

19.

Kabore N, Poda A, Zoungrana J, Da O, Ciaffi L, Semde A . Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting. BMC Nephrol. 2019; 20(1):155. PMC: 6505177. DOI: 10.1186/s12882-019-1335-9. View

20.

Malvestutto C, Aberg J . Management of dyslipidemia in HIV-infected patients. Clin Lipidol. 2012; 6(4):447-462. PMC: 3249059. DOI: 10.2217/clp.11.25. View