Studies on Liver Toxicants. Mixed-function Oxidase Activities and Hemoprotein Contents in Livers of Rats Poisoned with Bromobenzene

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1987 Jan 1

PMID 3619632

Authors

F E Beyhl

D G Mayer

Affiliations

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Abstract

In liver microsomes of rats 5 h after intraperitoneal administration of bromobenzene, the activities of a series of drug-metabolizing mixed-function oxidases, i.e., ketamine and aminopyrine N-demethylases, methylayapanine and methoxybiphenyl O-demethylases, and ethoxycoumarin O-deethylase, as well as glutathione and cytochrome b5 contents were found to be decreased, whereas the activities of microsomal, NADPH-dependent cytochrome c and neotetrazolium reductases as well as cytochrome P-450 were unchanged.

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