Polymorphisms Associated with Susceptibility to House Dust Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population

Overview

Journal J Asthma Allergy

Publisher Dove Medical Press

Date 2022 Oct 5

PMID 36196093

Authors

Xin-Yuan Chen

Xin-Jie Zhu

Min Chen

Mei-Ping Lu

Mei-Lin Wang

Min Yin

Ruo-Xi Chen

Zhong-Fei Wu

Dong-Yun Bu

Zheng-Dong Zhang

Lei Cheng

Affiliations

Soon will be listed here.

Abstract

Background: Genetic variants in (also known as ) have been reported to have significant associations with asthma and eczema in special populations, but little is known about allergic rhinitis. This study purposes to evaluate the association of single nucleotide polymorphisms (SNPs) in with house dust mite (HDM)-sensitized persistent allergic rhinitis (PER) in a population of Han Chinese.

Methods: In this hospital-based case-control study, 534 HDM-sensitized PER patients and 451 healthy controls were recruited from East China. In this population, six SNPs in were identified. Serum total and specific IgE levels were measured with ImmunoCAP. Secondary structure and minimum free energy were predicted by RNAfold.

Results: rs79525962 was associated with the risk of HDM-sensitized PER ( < 0.05). The individuals with CT+TT genotype demonstrated a higher risk of HDM-sensitized PER than those with CC genotype (adjusted OR = 1.393, 95% CI = 1.019-1.904). The homozygous genotype CC of rs3781699 rendered a lower risk of HDM-sensitized PER than the wild-type genotype AA (adjusted OR = 0.646, 95% CI = 0.427-0.976); however, the genotype and allele frequencies of rs3781699 demonstrated no associations with HDM-sensitized PER ( > 0.05). rs79525962 increased the risk of HDM-sensitized PER in the subgroup aged ≥16 years (adjusted OR = 1.745, 95% CI = 1.103-2.760), and this high risk was also found in the females (adjusted OR = 1.708, 95% CI = 1.021-2.856). The G-C haplotype of rs1320646-rs3781699 rendered a lower risk of HDM-sensitized PER than the common haplotype G-A (adjusted OR = 0.819, 95% CI = 0.676-0.993). The secondary structure of altered in response to different genotypes of rs79525962 and rs3781699.

Conclusion: SNP rs79525962 in the gene marks a risk locus of HDM-sensitized PER in Chinese Hans.

Citing Articles

Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis.

Chong A, Visitsunthorn K, Ong P J Asthma Allergy. 2022; 15:1681-1700.

PMID: 36447957 PMC: 9701514. DOI: 10.2147/JAA.S293900.

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