L: An Updated Review of Phytochemicals and Biological Activities

Overview

Journal Avicenna J Phytomed

Publisher Mashhad University of Medical Sciences

Date 2022 Oct 3

PMID 36186937

Authors

Seifollah Bahramikia

Parvaneh Hemmati Hassan Gavyar

Razieh Yazdanparast

Affiliations

Soon will be listed here.

Abstract

Objective: Medicinal plants and their components are potential novel sources for developing drugs against various diseases. L. (syn L. or felty germander) from the Lamiaceae family, is widely distributed in the dry and stony places of the hills and deserts of almost all Mediterranean countries, southwestern Asia, Europe, and North Africa. Based on traditional Iranian medicine (TIM), is used for treating many diseases, including abdominal pain, indigestion, and type 2 diabetes.

Materials And Methods: In our previous review article published in 2012 and based on 100 articles published from 1970 to 2010, the main compounds purified from were terpenes, terpenoids, and flavonoids with antioxidant, anticancer, anti-inflammatory, hypoglycemic, hepatoprotective, hypolipidemic, antibacterial, and antifungal activities.

Results: In this article, the phytochemistry and pharmacological activities of the plant reported from 2011 to 2020 have been evaluated. Therefore, a search was done in the databases PubMed, Science Direct and Google Scholar, Scopus, and Web of Science with the terms "," "." and felty germander', which included about 100 articles published since 2011 about pharmacological activities and isolated compounds. Most studies of this review focused on the antioxidant and antidiabetic effects of the plant.

Conclusion: Considering the position of in folk medicine, mainly as an antidiabetic agent, purification, structural and biological characterization of the active components appears essential for effective use of the plant.

Citing Articles

Acute Kidney Failure and Hemolysis Secondary to High-Dose (Lamiaceae): Case Report.

Gholami L, Ahmadi S, Pursusan S Clin Case Rep. 2025; 13(3):e70294.

PMID: 40034718 PMC: 11873361. DOI: 10.1002/ccr3.70294.

Prediction of the Binding to the Nuclear Factor NF-Kappa-B by Constituents from L. Essential Oil.

de Barros R, da Costa R, Guenane N, Bakchiche B, Benaceur F, Elkiran O Curr Issues Mol Biol. 2025; 47(1).

PMID: 39852163 PMC: 11763555. DOI: 10.3390/cimb47010048.

Evaluation of Yield, Chemical Profile, and Antimicrobial Activity of Teucrium polium L. Essential Oil Used in Iranian Folk Medicine.

Ghavam M, Markabi F Appl Biochem Biotechnol. 2024; 196(9):6134-6150.

PMID: 38194183 DOI: 10.1007/s12010-023-04847-6.

Protective potential effects of hydroalcoholic extract of L. (Lamiaceae) against paraquat-induced lung fibrosis: An experimental study in rats.

Molavinia S, Goudarzi M, Azemi M, Basir Z, Khorasgani Z, Rashidi Nooshabadi M Avicenna J Phytomed. 2023; 13(5):551-561.

PMID: 38089422 PMC: 10711580. DOI: 10.22038/AJP.2023.22121.

References

Ouelbani R, Bensari S, Mouas T, Khelifi D . Ethnobotanical investigations on plants used in folk medicine in the regions of Constantine and Mila (North-East of Algeria). J Ethnopharmacol. 2016; 194:196-218. DOI: 10.1016/j.jep.2016.08.016. View

Bezic N, Vuko E, Dunkic V, Ruscic M, Blazevic I, Burcul F . Antiphytoviral activity of sesquiterpene-rich essential oils from four croatian teucrium species. Molecules. 2011; 16(9):8119-29. PMC: 6264614. DOI: 10.3390/molecules16098119. View

Baluchnejadmojarad T, Roghani M, Roghani-Dehkordi F . Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. J Ethnopharmacol. 2005; 97(2):207-10. DOI: 10.1016/j.jep.2004.10.030. View

Khoshnood-Mansoorkhani M, Moein M, Oveisi N . Anticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice. Iran J Pharm Res. 2014; 9(4):395-401. PMC: 3870063. View

Lobbens E, Vissing K, Jorgensen L, van de Weert M, Jager A . Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity. J Ethnopharmacol. 2017; 200:66-73. DOI: 10.1016/j.jep.2017.02.020. View

Simonyan K, Chavushyan V . Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats. BMC Complement Altern Med. 2016; 16(1):415. PMC: 5078961. DOI: 10.1186/s12906-016-1407-3. View

Alizadeh A, Sohanaki H, Khaniki M, Mohaghgheghi M, Ghmami G, Mosavi M . The effect of teucrium polium honey on the wound healing and tensile strength in rat. Iran J Basic Med Sci. 2013; 14(6):499-505. PMC: 3586860. View

Sheikhbahaei F, Khazaei M, Nematollahi-Mahani S . Extract Enhances the Anti-Angiogenesis Effect of Tranilast on Human Umbilical Vein Endothelial Cells. Adv Pharm Bull. 2018; 8(1):131-139. PMC: 5896388. DOI: 10.15171/apb.2018.016. View

Gharaibeh M, Elayan H, Salhab A . Hypoglycemic effects of Teucrium polium. J Ethnopharmacol. 1988; 24(1):93-9. DOI: 10.1016/0378-8741(88)90139-0. View

10.

Bahramikia S, Yazdanparast R . Phytochemistry and medicinal properties of Teucrium polium L. (Lamiaceae). Phytother Res. 2012; 26(11):1581-93. DOI: 10.1002/ptr.4617. View

11.

Tariq M, Ageel A, Al-Yahya M, Mossa J, Al-Said M . Anti-inflammatory activity of Teucrium polium. Int J Tissue React. 1989; 11(4):185-8. View

12.

Mahmoudabady M, Haghshenas M, Niazmand S . Extract from . Protects Rat Heart against Oxidative Stress Induced by Ischemic-reperfusion Injury. Adv Biomed Res. 2018; 7:15. PMC: 5812096. DOI: 10.4103/abr.abr_218_16. View

13.

Hosseinkhani A, Falahatzadeh M, Raoofi E, Zarshenas M . An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine. J Evid Based Complementary Altern Med. 2016; 22(2):334-343. PMC: 5871189. DOI: 10.1177/2156587216654773. View

14.

Dag M, Ozturk Z, Aydnl M, Koruk I, Kadayfc A . Postpartum hepatotoxicity due to herbal medicine Teucrium polium. Ann Saudi Med. 2015; 34(6):541-3. PMC: 6074566. DOI: 10.5144/0256-4947.2014.541. View

15.

Sadeghi Z, Kuhestani K, Abdollahi V, Mahmood A . Ethnopharmacological studies of indigenous medicinal plants of Saravan region, Baluchistan, Iran. J Ethnopharmacol. 2014; 153(1):111-8. DOI: 10.1016/j.jep.2014.01.007. View

16.

Safaeian L, Ghanadian M, Shafiee-Moghadam Z . Antihyperlipidemic Effect of Different Fractions Obtained from Hydroalcoholic Extract in Rats. Int J Prev Med. 2018; 9:30. PMC: 5869962. DOI: 10.4103/ijpvm.IJPVM_100_17. View

17.

Ali-Shtayeh M, Jamous R, Jamous R . Traditional Arabic Palestinian ethnoveterinary practices in animal health care: A field survey in the West Bank (Palestine). J Ethnopharmacol. 2016; 182:35-49. DOI: 10.1016/j.jep.2016.02.005. View

18.

Khajoei Nasab F, Khosravi A . Ethnobotanical study of medicinal plants of Sirjan in Kerman Province, Iran. J Ethnopharmacol. 2014; 154(1):190-7. DOI: 10.1016/j.jep.2014.04.003. View

19.

Amiri M, Joharchi M . Ethnobotanical investigation of traditional medicinal plants commercialized in the markets of Mashhad, Iran. Avicenna J Phytomed. 2014; 3(3):254-71. PMC: 4075713. View

20.

Stankovic M, Curcic M, Zizic J, Topuzovic M, Solujic S, Markovic S . Teucrium plant species as natural sources of novel anticancer compounds: antiproliferative, proapoptotic and antioxidant properties. Int J Mol Sci. 2011; 12(7):4190-205. PMC: 3155345. DOI: 10.3390/ijms12074190. View