An Overview on Plant Derived Phenolic Compounds and Their Role in Treatment and Management of Diabetes

Overview

Journal J Pharmacopuncture

Date 2022 Oct 3

PMID 36186092

Authors

Himangshu Deka

Ananta Choudhury

Biplab Kumar Dey

Affiliations

Soon will be listed here.

Abstract

Objectives: In recent decades, the trend for treating diabetes mellitus (DM) has shifted toward alternative medicines that are obtained from plant sources. Existing literature suggests that phenolic compounds derived from plants possess promising health-promoting properties. This study aimed to discuss the role of plant-derived phenolic compounds in the effective treatment and management of diabetes.

Methods: Information about plant secondary metabolites, phenolic compounds, and their role in the treatment and management of diabetes was collected from different databases, such as Pubmed, ScienceDirect, Scopus, and Google Scholar. Keywords like secondary metabolites, phenolic compounds, simple phenol, flavonoids, lignans, stilbenes, and diabetes were searched. Research and review articles with relevant information were included in the study.

Results: Anti-diabetic studies of the four major classes of phenolic compounds were included in this review. The plant-derived phenolic compounds were reported to have potent anti-diabetic activities. However, each class of phenolic compounds was found to behave differently according to various mechanisms.

Conclusion: The obtained results suggest that phenolic compounds derived from natural sources display promising anti-diabetic activities. Based on the available information, it can be concluded that phenolic compounds obtained from various natural sources play key roles in the treatment and management of diabetes.

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References

Ahad A, Ganai A, Mujeeb M, Siddiqui W . Chrysin, an anti-inflammatory molecule, abrogates renal dysfunction in type 2 diabetic rats. Toxicol Appl Pharmacol. 2014; 279(1):1-7. DOI: 10.1016/j.taap.2014.05.007. View

Fiori J, Shin Y, Kim W, Krzysik-Walker S, Gonzalez-Mariscal I, Carlson O . Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes. 2013; 62(10):3500-13. PMC: 3781448. DOI: 10.2337/db13-0266. View

Alkhalidy H, Moore W, Wang Y, Luo J, McMillan R, Zhen W . The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production. Molecules. 2018; 23(9). PMC: 6192519. DOI: 10.3390/molecules23092338. View

Ghorbani A . Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017; 96:305-312. DOI: 10.1016/j.biopha.2017.10.001. View

Huang D, Chang W, Wu J, Shih R, Shen S . Gallic acid ameliorates hyperglycemia and improves hepatic carbohydrate metabolism in rats fed a high-fructose diet. Nutr Res. 2015; 36(2):150-60. DOI: 10.1016/j.nutres.2015.10.001. View

Golawska S, Sprawka I, Lukasik I, Golawski A . Are naringenin and quercetin useful chemicals in pest-management strategies?. J Pest Sci (2004). 2014; 87:173-180. PMC: 3925296. DOI: 10.1007/s10340-013-0535-5. View

Amin M, Arbid M . Estimation of ellagic acid and/or repaglinide effects on insulin signaling, oxidative stress, and inflammatory mediators of liver, pancreas, adipose tissue, and brain in insulin resistant/type 2 diabetic rats. Appl Physiol Nutr Metab. 2017; 42(2):181-192. DOI: 10.1139/apnm-2016-0429. View

Zhang Y, Liu D . Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol. 2011; 670(1):325-32. DOI: 10.1016/j.ejphar.2011.08.011. View

Bak E, Kim J, Choi Y, Kim J, Lee D, Woo G . Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. Clin Nutr. 2013; 33(1):156-63. DOI: 10.1016/j.clnu.2013.03.013. View

10.

Naz S, Imran M, Rauf A, Orhan I, Shariati M, Iahtisham-Ul-Haq . Chrysin: Pharmacological and therapeutic properties. Life Sci. 2019; 235:116797. DOI: 10.1016/j.lfs.2019.116797. View

11.

Kumar N, Goel N . Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnol Rep (Amst). 2019; 24:e00370. PMC: 6734135. DOI: 10.1016/j.btre.2019.e00370. View

12.

Oboh G, Agunloye O, Adefegha S, Akinyemi A, Ademiluyi A . Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J Basic Clin Physiol Pharmacol. 2014; 26(2):165-70. DOI: 10.1515/jbcpp-2013-0141. View

13.

Orsolic N, Sirovina D, Odeh D, Gajski G, Balta V, Sver L . Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse. Molecules. 2021; 26(11). PMC: 8199327. DOI: 10.3390/molecules26113262. View

14.

Yang Z, Kulkarni K, Zhu W, Hu M . Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem. 2012; 12(10):1264-80. PMC: 4010305. DOI: 10.2174/187152012803833107. View

15.

Lin D, Xiao M, Zhao J, Li Z, Xing B, Li X . An Overview of Plant Phenolic Compounds and Their Importance in Human Nutrition and Management of Type 2 Diabetes. Molecules. 2016; 21(10). PMC: 6274266. DOI: 10.3390/molecules21101374. View

16.

Salehi B, Ata A, Anil Kumar N, Sharopov F, Ramirez-Alarcon K, Ruiz-Ortega A . Antidiabetic Potential of Medicinal Plants and Their Active Components. Biomolecules. 2019; 9(10). PMC: 6843349. DOI: 10.3390/biom9100551. View

17.

Liu Y, Fu X, Lan N, Li S, Zhang J, Wang S . Luteolin protects against high fat diet-induced cognitive deficits in obesity mice. Behav Brain Res. 2014; 267:178-88. DOI: 10.1016/j.bbr.2014.02.040. View

18.

Draganescu D, Andritoiu C, Hritcu D, Dodi G, Popa M . Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats. Biology (Basel). 2021; 10(1). PMC: 7827730. DOI: 10.3390/biology10010043. View

19.

Jung U, Lee M, Park Y, Jeon S, Choi M . Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. J Pharmacol Exp Ther. 2006; 318(2):476-83. DOI: 10.1124/jpet.106.105163. View

20.

Unnikrishnan R, Anjana R, Mohan V . Diabetes mellitus and its complications in India. Nat Rev Endocrinol. 2016; 12(6):357-70. DOI: 10.1038/nrendo.2016.53. View