Perspectives of Lipid Metabolism Reprogramming in Head and Neck Squamous Cell Carcinoma: An Overview

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Oct 3

PMID 36185215

Authors

Xiangwan Miao

Beilei Wang

Kaili Chen

Rui Ding

Jichang Wu

Yi Pan

Peilin Ji

Bin Ye

Mingliang Xiang

Affiliations

Soon will be listed here.

Abstract

Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the "vital" cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism.

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