The Palladium-based Complexes Bearing 1,3-dibenzylbenzimidazolium with Morpholine, Triphenylphosphine, and Pyridine Derivate Ligands: Synthesis, Characterization, Structure and Enzyme Inhibitions

Overview

Journal Heliyon

Specialty Social Sciences

Date 2022 Oct 3

PMID 36185151

Authors

Aydin Aktas

Gul Yakali

Yeliz Demir

Ilhami Gulcin

Muhittin Aygun

Yetkin Gok

Affiliations

Soon will be listed here.

Abstract

The palladium-based complexes bearing -heterocyclic carbene (NHC) ligand have long attracted attention as active catalysts for many catalytic reactions. Recently, the biological activities of these complexes, which are stable to air and moisture, have also been wondered. With the aim, we report the synthesis of a series of (NHC)Pd(Br)(L) complexes (NHC: 1,3-dibenzylbenzimidazolium, L: morpholine, triphenylphosphine, pyridine, 3-chloropyridine, and 2-aminopyridine). All complexes were characterized by NMR (H and C), FTIR spectroscopic and elemental analysis techniques. In addition, the single crystal structures of the complex , , and were determined through single crystal x-ray crystallographic method. Furthermore, the carbonic anhydrase I and II isoenzymes (hCAs) and acetylcholinesterase (AChE) inhibition effects of these palladium-based complexes bearing NHC ligand were investigated. They showed highly potent inhibition effect with K values are between 10.06 ± 1.49-68.56 ± 11.53 nM for hCA I isoenzyme, 7.74 ± 0.66 to 49.39 ± 6.50 nM for hCA II isoenzyme and 22.83 ± 3.21 to 64.09 ± 9.05 nM for AChE enzyme.

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