Antineutrophil Cytoplasmic Antibody-associated Vasculitis After COVID-19 Vaccination with Pfizer-BioNTech

Overview

Journal Intern Med

Specialty General Medicine

Date 2022 Oct 2

PMID 36184535

Authors

Minami Suzuki

Yuta Sekiguchi

Masato Sasaki

Shunsuke Inaba

Sakino Oyama

Yuichi Inoue

Masahiro Warabi

Kenichi Ohashi

Seiji Inoshita

Affiliations

Soon will be listed here.

Abstract

The extent of rare side effects of mRNA vaccines for coronavirus disease 2019 (COVID-19) remains unclear. Several cases of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) following COVID-19 vaccination have been reported. We herein report a 72-year-old man who presented with a fever after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine. He was diagnosed with acute kidney injury due to myeloperoxidase-ANCA-associated vasculitis and was treated with intermittent hemodialysis, high-dose prednisolone, and intravenous rituximab. His general symptoms and renal impairment subsequently improved. When systemic symptoms are prolonged or renal abnormalities appear after COVID-19 vaccination, the possibility of AAV should be considered.

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