Barriers to Anti-retroviral Therapy Adherence Among Adolescents Aged 10 to 19 Years Living with HIV in Sub-Saharan Africa: A Mixed-methods Systematic Review Protocol

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2022 Sep 30

PMID 36178934

Authors

Londiwe D Hlophe

Jacques L Tamuzi

Constance Shumba

Peter S Nyasulu

Affiliations

Soon will be listed here.

Abstract

Background: Antiretroviral therapy (ART) adherence is fundamental in achieving viral load suppression and consequently attaining positive health outcomes among people living with HIV. However, ART adherence is sub-optimum among adolescents living with HIV (ALHIV) thus the high AIDS-related mortality even after World Health Organization (WHO) revised HIV treatment eligibility guidelines in 2010, 2013 and 2016. Consolidated trends of barriers to ART adherence among ALHIV aged 10 to 19 years in sub-Saharan countries post each eligibility guidelines revision to date are unknown.

Methods And Analysis: We will conduct comprehensive search of peer-reviewed and grey literature databases publishing observational studies reporting data adherence and barriers to ART among ALHIV on ART. We will further search the reference lists of included studies and other relevant reviews. We will also do a citation search for included studies in the review. We will search in the following databases PubMed, Cochrane Review, Scopus on Excerpta Medica Database (Embase) and Cumulated Index to Nursing and Allied Health Literature (CINAHL). Furthermore WHO, Joint United Nations Programme on HIV/AIDS (UNAIDS) websites, conference proceedings and country reports will be searched to identify relevant literature. Data will be extracted from eligible studies and synthesis will be through categorizing studies by year of study, barriers, and outcomes. Meta-analysis and meta-synthesis will be conducted for quantitative and qualitative data, respectively. Where meta-synthesis is impossible, narrative synthesis will be conducted. We will only include studies conducted between 2010 and 2022 within sub-Saharan Africa countries.

Discussion: Adherence to ART at a high level is required to achieve adequate viral suppression and improve quality of life in ALHIV. The knowledge of barriers to ART among ALHV may aid in the design of interventions aimed at improving ART adherence.

Trail Registration: Systematic review protocol registration: PROSPERO CRD42021284891.

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References

Stafford K, Odafe S, Lo J, Ibrahim R, Ehoche A, Niyang M . Evaluation of the clinical outcomes of the Test and Treat strategy to implement Treat All in Nigeria: Results from the Nigeria Multi-Center ART Study. PLoS One. 2019; 14(7):e0218555. PMC: 6619660. DOI: 10.1371/journal.pone.0218555. View

Shubber Z, Mills E, Nachega J, Vreeman R, Freitas M, Bock P . Patient-Reported Barriers to Adherence to Antiretroviral Therapy: A Systematic Review and Meta-Analysis. PLoS Med. 2016; 13(11):e1002183. PMC: 5127502. DOI: 10.1371/journal.pmed.1002183. View

Smith R, Villanueva G, Probyn K, Sguassero Y, Ford N, Orrell C . Accuracy of measures for antiretroviral adherence in people living with HIV. Cochrane Database Syst Rev. 2022; 7:CD013080. PMC: 9309033. DOI: 10.1002/14651858.CD013080.pub2. View

Shroufi A, Gunguwo H, Dixon M, Nyathi M, Ndebele W, Saint-Sauveur J . HIV-infected adolescents in southern Africa can achieve good treatment outcomes: results from a retrospective cohort study. AIDS. 2013; 27(12):1971-8. PMC: 3713766. DOI: 10.1097/QAD.0b013e32836149ea. View

Kim S, Gerver S, Fidler S, Ward H . Adherence to antiretroviral therapy in adolescents living with HIV: systematic review and meta-analysis. AIDS. 2014; 28(13):1945-56. PMC: 4162330. DOI: 10.1097/QAD.0000000000000316. View

Ferrand R, Briggs D, Ferguson J, Penazzato M, Armstrong A, MacPherson P . Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges. Trop Med Int Health. 2015; 21(3):325-33. PMC: 4776345. DOI: 10.1111/tmi.12656. View

Chhim K, Mburu G, Tuot S, Sopha R, Khol V, Chhoun P . Factors associated with viral non-suppression among adolescents living with HIV in Cambodia: a cross-sectional study. AIDS Res Ther. 2018; 15(1):20. PMC: 6240223. DOI: 10.1186/s12981-018-0205-z. View

Liu T, Hogan J, Daniels M, Coetzer M, Xu Y, Bove G . Improved HIV-1 Viral Load Monitoring Capacity Using Pooled Testing With Marker-Assisted Deconvolution. J Acquir Immune Defic Syndr. 2017; 75(5):580-587. PMC: 5503773. DOI: 10.1097/QAI.0000000000001424. View

Evans S, Mellins C, Leu C, Warne P, Elkington K, Dolezal C . HIV treatment adherence measurement and reporting concordance in youth with perinatally acquired HIV infection and their caregivers. AIDS Patient Care STDS. 2014; 29(1):43-51. PMC: 4281858. DOI: 10.1089/apc.2014.0058. View

10.

Tong A, Sainsbury P, Craig J . Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007; 19(6):349-57. DOI: 10.1093/intqhc/mzm042. View

11.

Murray K, Dulli L, Ridgeway K, Santo L, Darrow de Mora D, Olsen P . Improving retention in HIV care among adolescents and adults in low- and middle-income countries: A systematic review of the literature. PLoS One. 2017; 12(9):e0184879. PMC: 5621671. DOI: 10.1371/journal.pone.0184879. View

12.

Ridgeway K, Dulli L, Murray K, Silverstein H, Santo L, Olsen P . Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature. PLoS One. 2018; 13(1):e0189770. PMC: 5749726. DOI: 10.1371/journal.pone.0189770. View

13.

Enane L, Davies M, Leroy V, Edmonds A, Apondi E, Adedimeji A . Traversing the cascade: urgent research priorities for implementing the 'treat all' strategy for children and adolescents living with HIV in sub-Saharan Africa. J Virus Erad. 2018; 4(Suppl 2):40-46. PMC: 6248846. View

14.

Olubajo B, Mitchell-Fearon K, Ogunmoroti O . A Comparative Systematic Review of the Optimal CD4 Cell Count Threshold for HIV Treatment Initiation. Interdiscip Perspect Infect Dis. 2014; 2014:625670. PMC: 3981164. DOI: 10.1155/2014/625670. View

15.

Tong A, Flemming K, Mcinnes E, Oliver S, Craig J . Enhancing transparency in reporting the synthesis of qualitative research: ENTREQ. BMC Med Res Methodol. 2012; 12:181. PMC: 3552766. DOI: 10.1186/1471-2288-12-181. View

16.

Ammon N, Mason S, Corkery J . Factors impacting antiretroviral therapy adherence among human immunodeficiency virus-positive adolescents in Sub-Saharan Africa: a systematic review. Public Health. 2018; 157:20-31. DOI: 10.1016/j.puhe.2017.12.010. View

17.

Walensky R, Wood R, Ciaranello A, Paltiel A, Lorenzana S, Anglaret X . Scaling up the 2010 World Health Organization HIV Treatment Guidelines in resource-limited settings: a model-based analysis. PLoS Med. 2011; 7(12):e1000382. PMC: 3014084. DOI: 10.1371/journal.pmed.1000382. View

18.

Bor J, Fox M, Rosen S, Venkataramani A, Tanser F, Pillay D . Treatment eligibility and retention in clinical HIV care: A regression discontinuity study in South Africa. PLoS Med. 2017; 14(11):e1002463. PMC: 5705070. DOI: 10.1371/journal.pmed.1002463. View

19.

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. PMC: 8005924. DOI: 10.1136/bmj.n71. View

20.

Renju J, Seeley J, Moshabela M, Wringe A . Understanding the health systems impacts of Universal Test and Treat in sub-Saharan Africa: The Shape UTT study. Glob Public Health. 2020; 16(2):161-166. DOI: 10.1080/17441692.2020.1861317. View