[Research Advances on the Role of Acid Fibroblast Growth Factor in Promotion of Wound Healing]

Overview

Journal Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi

Date 2022 Sep 30

PMID 36177591

Authors

H T Wang

J T Han

D H Hu

Affiliations

Soon will be listed here.

Abstract

Acid fibroblast growth factor (aFGF) is a member of fibroblast growth factors (FGF) family, widely promoting embryonic development, wound healing, vascular regeneration, nerve injury repair, as well as regulating immune metabolism. Many pathophysiological processes, such as inflammation, neovascularization, proliferation and migration of repair cells, and deposition of collagen and other extracellular matrix are involved in the process of wound healing. Based on the relevant literature in recent years, this article mainly reviews the research progresses on the roles and mechanism of aFGF in biological signal transduction, regulation of cell growth, and involvement in tissue repair, and discusses the current research hot spots as well as the prospective future direction of clinical applications of aFGF in the aspect of clinical pharmacokinetics and safety.

Citing Articles

Acidic fibroblast growth factor inhibits reactive oxygen species-induced epithelial-mesenchymal transdifferentiation in vascular endothelial cells via the miR-155-5p/SIRT1/Nrf2/HO-1 pathway to promote wound healing in diabetic mice.

Zhang Y, Hei F, Xiao Y, Liu Y, Han J, Hu D Burns Trauma. 2024; 12:tkae010.

PMID: 38803612 PMC: 11129767. DOI: 10.1093/burnst/tkae010.

References

Li C, Deng C, Zhou T, Hu J, Dai B, Yi F . MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis. Int J Biol Sci. 2021; 17(7):1795-1807. PMC: 8120458. DOI: 10.7150/ijbs.59715. View

Cha H, Hong S, Park J, Park H . Stem Cell-Derived Exosomes and Nanovesicles: Promotion of Cell Proliferation, Migration, and Anti-Senescence for Treatment of Wound Damage and Skin Ageing. Pharmaceutics. 2020; 12(12). PMC: 7761250. DOI: 10.3390/pharmaceutics12121135. View

Hui Q, Zhang L, Yang X, Yu B, Huang Z, Pang S . Higher Biostability of rh-aFGF-Carbomer 940 Hydrogel and Its Effect on Wound Healing in a Diabetic Rat Model. ACS Biomater Sci Eng. 2021; 4(5):1661-1668. DOI: 10.1021/acsbiomaterials.8b00011. View

Li R, Wang B, Wu C, Li D, Wu Y, Ye L . Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage. Cell Death Dis. 2021; 12(1):107. PMC: 7819983. DOI: 10.1038/s41419-021-03407-2. View

Bucur M, Dinca O, Vladan C, Popp C, Nichita L, Cioplea M . Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars. J Immunol Res. 2019; 2018:5196023. PMC: 6304192. DOI: 10.1155/2018/5196023. View

Zou Y, Hu J, Huang W, Ye S, Han F, Du J . Non-Mitogenic Fibroblast Growth Factor 1 Enhanced Angiogenesis Following Ischemic Stroke by Regulating the Sphingosine-1-Phosphate 1 Pathway. Front Pharmacol. 2020; 11:59. PMC: 7063943. DOI: 10.3389/fphar.2020.00059. View

Akbari H, Ahmadi M, Fatemi M, Foroutan A, Akbari P, Bagheri H . The Role of Recombinant Fibroblast Growth Factor 1 in Enhancing the Angiogenesis in Random Cutaneous Flaps in Animal Model of Rat. World J Plast Surg. 2021; 10(2):76-81. PMC: 8290444. DOI: 10.29252/wjps.10.2.76. View

Guan J, Li X, Peng D, Zhang W, Qu J, Lu F . MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A. Front Pharmacol. 2020; 11:276. PMC: 7076186. DOI: 10.3389/fphar.2020.00276. View

Cheng X, Wang Z, Yang J, Ma M, Lu T, Xu G . Acidic fibroblast growth factor delivered intranasally induces neurogenesis and angiogenesis in rats after ischemic stroke. Neurol Res. 2011; 33(7):675-80. DOI: 10.1179/1743132810Y.0000000004. View

10.

Zulueta M, Chyan C, Hung S . Structural analysis of synthetic heparan sulfate oligosaccharides with fibroblast growth factors and heparin-binding hemagglutinin. Curr Opin Struct Biol. 2018; 50:126-133. DOI: 10.1016/j.sbi.2018.03.003. View

11.

Zhang J, Ge J, Xu Y, Chen J, Zhou A, Sun L . Bioactive multi-engineered hydrogel offers simultaneous promise against antibiotic resistance and wound damage. Int J Biol Macromol. 2020; 164:4466-4474. DOI: 10.1016/j.ijbiomac.2020.08.247. View

12.

Tan F, Rui X, Xiang X, Yu Z, Al-Rubeai M . Multimodal treatment combining cold atmospheric plasma and acidic fibroblast growth factor for multi-tissue regeneration. FASEB J. 2021; 35(5):e21442. DOI: 10.1096/fj.202002611R. View

13.

Zakrzewska M, Opalinski L, Haugsten E, Otlewski J, Wiedlocha A . Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling. Int J Mol Sci. 2019; 20(8). PMC: 6514807. DOI: 10.3390/ijms20081826. View

14.

Bruczko-Goralewska M, Romanowicz L, Baczyk J, Wolanska M, Sobolewski K, Kowalewski R . Peptide growth factors and their receptors in the vein wall. J Investig Med. 2019; 67(8):1149-1154. DOI: 10.1136/jim-2019-001075. View

15.

Weng T, Cai C, Han C, Wang X . [Research advances on biomaterials for the delivery of growth factors to regulate wound repair]. Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022; 38(7):691-696. PMC: 11704506. DOI: 10.3760/cma.j.cn501225-20220430-00166. View

16.

Wang F, Wang Y, Tian C, Xu S, Wang R, Hou K . Fabrication of the FGF1-functionalized sericin hydrogels with cell proliferation activity for biomedical application using genetically engineered Bombyx mori (B. mori) silk. Acta Biomater. 2018; 79:239-252. DOI: 10.1016/j.actbio.2018.08.031. View

17.

He S, Shi D, Han Z, Dong Z, Xie Y, Zhang F . Heparinized silk fibroin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision. Biomed Eng Online. 2019; 18(1):97. PMC: 6775648. DOI: 10.1186/s12938-019-0716-4. View

18.

Zhang Q, Xu P, Lu Y, Dou H . Acidic and basic fibroblast growth factor expression levels in cervical cancer and their effects on tumor cell proliferation. Genet Mol Res. 2016; 15(4). DOI: 10.4238/gmr15049043. View

19.

Scheraga R, Thompson C, Tulapurkar M, Nagarsekar A, Cowan M, Potla R . Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium. Am J Physiol Lung Cell Mol Physiol. 2016; 311(5):L941-L955. PMC: 5130531. DOI: 10.1152/ajplung.00262.2016. View

20.

Sun J, Huang X, Niu C, Wang X, Li W, Liu M . aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β-catenin-mediated upregulation of HXK2. Redox Biol. 2020; 39:101811. PMC: 7772795. DOI: 10.1016/j.redox.2020.101811. View