Prophylactic Cholecystectomy: A Valuable Treatment Strategy for Cholecystolithiasis After Gastric Cancer Surgery

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Sep 30

PMID 36176409

Authors

Haipeng Liu

Jie Liu

Wei Xu

Xiao Chen

Affiliations

Soon will be listed here.

Abstract

The main treatment for gastric cancer is surgical excision. Gallstones are one of the common postoperative complications of gastric cancer. To avoid the adverse effects of gallstone formation after gastric cancer surgery, we reviewed the causes and risk factors and mechanisms involved in gallstone formation after gastric cancer surgery. The evidence and value regarding prophylactic cholecystectomy (PC) during gastric cancer surgery was also reviewed. Based on previous evidence, we summarized the mechanism and believe that injury or resection of the vagus nerve or changes in intestinal hormone secretion can lead to physiological dysfunction of the gallbladder and Oddi sphincter, and the lithogenic components in the bile are also changed, ultimately leading to CL. Previous studies also have identified many independent risk factors for CL after gastric cancer, such as type of gastrectomy, reconstruction of the digestive tract, degree of lymph node dissection, weight, liver function, sex, age, diabetes and gallbladder volume are closely related to CL development. At present, there are no uniform guidelines for the selection of treatment strategies. As a new treatment strategy, PC has undeniable advantages and is expected to become the standard treatment for CL after gastric cancer in the future. The individualized PC strategy for CL after gastric cancer is the main direction of future research.

Citing Articles

Gallstone formation and subsequent cholecystectomy after oncological gastric and esophageal resection.

Esswein K, Gehwolf P, Wykypiel H, Kafka-Ritsch R Langenbecks Arch Surg. 2024; 409(1):57.

PMID: 38337043 DOI: 10.1007/s00423-024-03242-x.

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