The Functions of N6-methyladenosine (m6A) RNA Modifications in Colorectal Cancer

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2022 Sep 29

PMID 36175777

Authors

Haiyan Qiao

Linfeng Liu

Jun Chen

Bingbing Shang

Liang Wang

Affiliations

Soon will be listed here.

Abstract

Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are some of the most common malignant tumors that are prone to distant metastasis. Its high incidence rate and high mortality rate have attracted much attention. In recent years, epigenetics has attracted increasing attention and has been the focus of many research studies. N6-methyladenosine(m6A) RNA modifications can modify eukaryotic mRNA to impact metabolism. The changes in the m6A regulatory genes are related to the occurrence and development of CRC and play an important role in the pathogenesis of CRC. The effect of m6A RNA modification is regulated by its related regulatory factors ("writer", "eraser", "reader"). In this review, we comprehensively analyzed the effect of m6A methylation on CRC and the relationship between the expression of related regulatory factors and the development and occurrence of CRC. Then, we summarized the roles of m6A and its regulatory factors in CRC and its potential clinical value, which provides a basis for further research on the mechanism of m6A methylation in CRC.

Citing Articles

New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy.

Li M, Tian H, Zhuang Y, Zhang Z Front Immunol. 2025; 16:1533940.

PMID: 39911396 PMC: 11794227. DOI: 10.3389/fimmu.2025.1533940.

Identification and Validation of a m6A-Related Long Noncoding RNA Prognostic Model in Colorectal Cancer.

Jiang P, Chu M, Liang Y J Cell Mol Med. 2025; 29(2):e70376.

PMID: 39868645 PMC: 11770481. DOI: 10.1111/jcmm.70376.

Regulation of mA (N-Methyladenosine) methylation modifiers in solid cancers.

Singh S, Gupta S, Abhishek R, Sachan M Funct Integr Genomics. 2024; 24(6):193.

PMID: 39438339 DOI: 10.1007/s10142-024-01467-z.

Interaction of the intestinal cytokines-JAKs-STAT3 and 5 axes with RNA N6-methyladenosine to promote chronic inflammation-induced colorectal cancer.

Esmaeili N, Bakheet A, Tse W, Liu S, Han X Front Oncol. 2024; 14:1352845.

PMID: 39136000 PMC: 11317299. DOI: 10.3389/fonc.2024.1352845.

METTL3-induced circ_0008345 contributes to the progression of colorectal cancer via the microRNA-182-5p/CYP1A2 pathway.

Hou C, Liu J, Liu J, Yao D, Liang F, Qin C BMC Cancer. 2024; 24(1):728.

PMID: 38877514 PMC: 11177402. DOI: 10.1186/s12885-024-12474-5.

References

Zhang C, Zhang L, Xu T, Xue R, Yu L, Zhu Y . Mapping the spreading routes of lymphatic metastases in human colorectal cancer. Nat Commun. 2020; 11(1):1993. PMC: 7181746. DOI: 10.1038/s41467-020-15886-6. View

Gong Y, Guo Y, Hai Y, Yang H, Liu Y, Yang S . Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway. Biomed Res Int. 2014; 2014:364134. PMC: 3947734. DOI: 10.1155/2014/364134. View

Fang Z, Hu Y, Hu J, Huang Y, Zheng S, Guo C . The crucial roles of N-methyladenosine (mA) modification in the carcinogenesis and progression of colorectal cancer. Cell Biosci. 2021; 11(1):72. PMC: 8034132. DOI: 10.1186/s13578-021-00583-8. View

Xu X, Huang J, Ocansey D, Xia Y, Zhao Z, Xu Z . The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer. J Inflamm Res. 2021; 14:3289-3306. PMC: 8289367. DOI: 10.2147/JIR.S320449. View

OKeefe S . Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol. 2016; 13(12):691-706. PMC: 6312102. DOI: 10.1038/nrgastro.2016.165. View

Grivennikov S . Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol. 2012; 35(2):229-44. PMC: 3568220. DOI: 10.1007/s00281-012-0352-6. View

Yu H, Hemminki K . Genetic epidemiology of colorectal cancer and associated cancers. Mutagenesis. 2019; 35(3):207-219. DOI: 10.1093/mutage/gez022. View

Thanikachalam K, Khan G . Colorectal Cancer and Nutrition. Nutrients. 2019; 11(1). PMC: 6357054. DOI: 10.3390/nu11010164. View

Valvano M, Magistroni M, Mancusi A, DAscenzo D, Longo S, Stefanelli G . The Usefulness of Serum Vitamin D Levels in the Assessment of IBD Activity and Response to Biologics. Nutrients. 2021; 13(2). PMC: 7910959. DOI: 10.3390/nu13020323. View

10.

Sun T, Wu R, Ming L . The role of m6A RNA methylation in cancer. Biomed Pharmacother. 2019; 112:108613. DOI: 10.1016/j.biopha.2019.108613. View

11.

He L, Li H, Wu A, Peng Y, Shu G, Yin G . Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 2019; 18(1):176. PMC: 6892141. DOI: 10.1186/s12943-019-1109-9. View

12.

Wang T, Kong S, Tao M, Ju S . The potential role of RNA N6-methyladenosine in Cancer progression. Mol Cancer. 2020; 19(1):88. PMC: 7216508. DOI: 10.1186/s12943-020-01204-7. View

13.

Lan Q, Liu P, Haase J, Bell J, Huttelmaier S, Liu T . The Critical Role of RNA mA Methylation in Cancer. Cancer Res. 2019; 79(7):1285-1292. DOI: 10.1158/0008-5472.CAN-18-2965. View

14.

Liu Z, Li L, Sun H, Liu S . Link Between m6A Modification and Cancers. Front Bioeng Biotechnol. 2018; 6:89. PMC: 6055048. DOI: 10.3389/fbioe.2018.00089. View

15.

Shen H, Lan Y, Zhao Y, Shi Y, Jin J, Xie W . The emerging roles of N6-methyladenosine RNA methylation in human cancers. Biomark Res. 2020; 8:24. PMC: 7325074. DOI: 10.1186/s40364-020-00203-6. View

16.

Liu X, Xiao M, Zhang L, Li L, Zhu G, Shen E . The m6A methyltransferase METTL14 inhibits the proliferation, migration, and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway. J Clin Lab Anal. 2020; 35(3):e23655. PMC: 7957981. DOI: 10.1002/jcla.23655. View

17.

Chen R, Chen X, Xia L, Zhang J, Pan Z, Ma X . N-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun. 2019; 10(1):4695. PMC: 6795808. DOI: 10.1038/s41467-019-12651-2. View

18.

Chen Y, Wang S, Cho W, Zhou X, Zhang Z . Prognostic Implication of the mA RNA Methylation Regulators in Rectal Cancer. Front Genet. 2021; 12:604229. PMC: 8209494. DOI: 10.3389/fgene.2021.604229. View

19.

Zhang Z, Wang Q, Zhang M, Zhang W, Zhao L, Yang C . Comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing. Epigenetics. 2020; 16(4):425-435. PMC: 7993153. DOI: 10.1080/15592294.2020.1805684. View

20.

Li W, Gao Y, Jin X, Wang H, Lan T, Wei M . Comprehensive analysis of N6-methylandenosine regulators and m6A-related RNAs as prognosis factors in colorectal cancer. Mol Ther Nucleic Acids. 2022; 27:598-610. PMC: 8753275. DOI: 10.1016/j.omtn.2021.12.007. View