A Prospective Analysis of Two Studies That Used the 5-mm Interval Slices and 5-mm Margin-free Method for Ipsilateral Breast Tumor Recurrence After Breast-conserving Surgery Without Radiotherapy

Overview

Journal Breast Cancer

Specialty Oncology

Date 2022 Sep 29

PMID 36175750

Authors

Shozo Ohsumi

Reiki Nishimura

Norikazu Masuda

Sadako Akashi-Tanaka

Kimito Suemasu

Hideko Yamauchi

Eriko Tokunaga

Tadashi Ikeda

Tsunehiro Nishi

Hiroto Hayashi

Yuichi Iino

Yuichi Takatsuka

Yasuo Ohashi

Hideo Inaji

Affiliations

Soon will be listed here.

Abstract

Background: Breast-conserving surgery with radiotherapy is one of standard treatments for early breast cancer. However, it is regarded as an option to treat elderly patients with small hormone receptor-positive breast cancer with breast-conserving surgery and hormone therapy without radiotherapy. We conducted two sequential prospective studies to examine the feasibility of breast-conserving surgery without radiotherapy since 2002 and present the results.

Patients And Methods: Primary female breast cancer patients who fulfilled the strict eligibility criteria were prospectively enrolled in two sequential studies named WORTH 1 and 2. The surgical materials were sliced in 5-mm intervals and all slices were examined microscopically. Postoperative radiotherapy was not allowed, but tamoxifen or anastrozole was administered for 5 years. Ipsilateral breast tumor recurrence (IBTR)-free survival was the primary outcome.

Results: The data of the two studies were combined (N = 321). The median follow-up period for IBTR was 94 months (4-192 months). Only three patients were treated with adjuvant chemotherapy. The 5- and 10-year IBTR-free rates were 97.0% and 90.5%, respectively. The age at operation and PR status affected IBTR rates independently. When we calculated IBTR-free rates of patients who were 65 years of age or older at the time of surgery and had PR-positive tumors, the 5- and 10-year IBTR rates were both 98.4%.

Conclusions: Our "5-mm-thick slice and 5-mm free-margin" method may be effective to select patients who can be treated by breast-conserving surgery and hormone therapy without radiotherapy.

Citing Articles

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HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution.

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