Contribution of Polymorphisms to Esophageal Cancer Risk Among the Chinese Han Population

Overview

Journal Pharmgenomics Pers Med

Publisher Dove Medical Press

Date 2022 Sep 29

PMID 36172401

Authors

Shuyong Yu

Guihong Yuan

Feixiang Hu

Yongyu Li

Zhuang Chen

Ronglin Zhang

Ping Li

Zhaowei Chen

Jian Song

Affiliations

Soon will be listed here.

Abstract

Background: was overexpressed in esophageal cancer (EC). The study aimed to identify genotypes of polymorphisms and their correlation with EC occurrence in a Chinese Han population.

Methods: Four single nucleotide polymorphisms (SNPs) in were randomly selected for genotyping through Agena MassARRAY system among 525 EC patients and 522 healthy controls. Multiple genetic models were applied to assess the association of polymorphisms with EC susceptibility by calculating odds ratios (ORs) with 95% confidence intervals (CIs).

Results: Rs10934270 was associated with lower EC susceptibility (OR = 0.64, = 0.004) with statistical power >90% in overall analysis. Specifically, the correlation of rs10934270 with EC susceptibility was found in subgroups including patients with esophageal squamous cell carcinoma (ESCC), males, subjects aged ≤65 years, subjects with BMI ≤ 24 kg/m, and smokers. Rs9841504 might be a risk-increasing factor for ESCC. Moreover, rs9288999 in subjects aged ≤65 years and rs73230612 in females were related to lower EC risk.

Conclusion: Our research is the first to report that rs10934270 is associated with reduced EC susceptibility in the Chinese Han population. These data provide a scientific basis for understanding the influence of the gene on EC occurrence.

Citing Articles

Overview of Risk Factors for Esophageal Squamous Cell Carcinoma in China.

Conway E, Wu H, Tian L Cancers (Basel). 2023; 15(23).

PMID: 38067307 PMC: 10705141. DOI: 10.3390/cancers15235604.

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