Endothelial Microparticles: A Mechanosensitive Regulator of Vascular Homeostasis and Injury Under Shear Stress

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Sep 29

PMID 36172284

Authors

Shuo Feng

Jia Wei Chen

Xin Yi Shu

Muladili Aihemaiti

Jin Wei Quan

Lin Lu

Rui Yan Zhang

Chen Die Yang

Xiao Qun Wang

Affiliations

Soon will be listed here.

Abstract

Hemodynamic shear stress (SS), a frictional force generated by blood flow, regulates vascular homeostasis. High and steady SS maintains physiological function of endothelial cells while low and disturbed SS promotes disturbance of vascular homeostasis and the development of atherosclerosis. Endothelial microparticle (EMP), a vesicular structure shed from endothelial cells, has emerged as a surrogate biomarker of endothelial injury and dysfunction. EMP release is triggered by disturbed SS in addition to multiple inflammatory cytokines. This review systematically summarizes the impact of SS on EMPs and the role of EMPs under SS in modulating vascular homeostasis and injury, including endothelial survival, vasodilation, inflammatory response, vascular permeability, and coagulation system.

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