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Myoclonic Jerks and Ataxia: A Case of Rare Neurological Side Effects of Amiodarone

Overview
Journal Cureus
Date 2022 Sep 29
PMID 36171835
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Abstract

We present the case of an 85-year-old man with a known medical history of recurrent ventricular arrhythmia and paroxysmal atrial fibrillation who was started on an amiodarone loading dose four days before presenting with tremors and balance impairment. Amiodarone's adverse effects in various systems have been well studied, although this is not the case with neurotoxic side effects. In this article, we discuss the neurotoxic side effects caused by amiodarone and the importance of a complete physical examination when starting this medication for supraventricular and ventricular arrhythmias.

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References
1.
Orr C, Ahlskog J . Frequency, characteristics, and risk factors for amiodarone neurotoxicity. Arch Neurol. 2009; 66(7):865-9. DOI: 10.1001/archneurol.2009.96. View

2.
Chokesuwattanaskul R, Shah N, Chokesuwattanaskul S, Liu Z, Thakur R . Low-dose Amiodarone Is Safe: A Systematic Review and Meta-analysis. J Innov Card Rhythm Manag. 2020; 11(4):4054-4061. PMC: 7192149. DOI: 10.19102/icrm.2020.110403. View

3.
Vorperian V, Havighurst T, Miller S, January C . Adverse effects of low dose amiodarone: a meta-analysis. J Am Coll Cardiol. 1997; 30(3):791-8. DOI: 10.1016/s0735-1097(97)00220-9. View

4.
Krauser D, Segal A, Kligfield P . Severe ataxia caused by amiodarone. Am J Cardiol. 2005; 96(10):1463-4. DOI: 10.1016/j.amjcard.2005.06.093. View

5.
Morady F, Sauve M, Malone P, Shen E, Schwartz A, Bhandari A . Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation. Am J Cardiol. 1983; 52(8):975-9. DOI: 10.1016/0002-9149(83)90515-5. View