Ventral Hippocampus-lateral Septum Circuitry Promotes Foraging-related Memory

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2022 Sep 28

PMID 36170832

Authors

Lea Decarie-Spain

Clarissa M Liu

Logan Tierno Lauer

Keshav Subramanian

Alexander G Bashaw

Molly E Klug

Isabella H Gianatiempo

Andrea N Suarez

Emily E Noble

Kristen N Donohue

Alyssa M Cortella

Joel D Hahn

Elizabeth A Davis

Scott E Kanoski

Affiliations

Soon will be listed here.

Abstract

Remembering the location of a food or water source is essential for survival. Here, we reveal that spatial memory for food location is reflected in ventral hippocampus (HPCv) neuron activity and is impaired by HPCv lesion. HPCv mediation of foraging-related memory involves communication to the lateral septum (LS), as either reversible or chronic disconnection of HPCv-to-LS signaling impairs spatial memory retention for food or water location. This neural pathway selectively encodes appetitive spatial memory, as HPCv-LS disconnection does not affect spatial memory for escape location in a negative reinforcement procedure, food intake, or social and olfactory-based appetitive learning. Neural pathway tracing and functional mapping analyses reveal that LS neurons recruited during the appetitive spatial memory procedure are primarily GABAergic neurons that project to the lateral hypothalamus. Collective results emphasize that the neural substrates controlling spatial memory are outcome specific based on reinforcer modality.

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