Sensory Loss and Risk of Dementia

Overview

Journal Neuroscientist

Publisher Sage Publications

Specialty Neurology

Date 2022 Sep 28

PMID 36169300

Authors

Meher Lad

William Sedley

Timothy D Griffiths

Affiliations

Soon will be listed here.

Abstract

Sensory loss in olfaction, vision, and hearing is a risk factor for dementia, but the reasons for this are unclear. This review presents the neurobiological evidence linking each sensory modality to specific dementias and explores the potential mechanisms underlying this. Olfactory deficits can be linked to direct neuropathologic changes in the olfactory system due to Alzheimer disease and Parkinson disease, and may be a marker of disease severity. Visual deficits potentially increase dementia risk in a vulnerable individual by reducing resilience to dementia. Hearing deficits may indicate a susceptibility to Alzheimer disease through a variety of mechanisms. More generally, sensory impairment could be related to factors associated with resilience against dementia. Further research is needed to tease out the specific and synergistic effects of sensory impairment. Studying sensory loss in relation to neurodegenerative biomarkers is necessary to clarify the mechanisms involved. This could produce new monitoring and management strategies for people at risk of dementia.

Citing Articles

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Subjective hearing loss is not associated with an increased risk of Alzheimer's disease dementia.

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References

McKeith I, Boeve B, Dickson D, Halliday G, Taylor J, Weintraub D . Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017; 89(1):88-100. PMC: 5496518. DOI: 10.1212/WNL.0000000000004058. View

Misiak M, Hipolito M, Ressom H, Obisesan T, Manaye K, Nwulia E . Apo E4 Alleles and Impaired Olfaction as Predictors of Alzheimer's Disease. Clin Exp Psychol. 2018; 3(4). PMC: 5800509. DOI: 10.4172/2471-2701.1000169. View

Leyland L, Bremner F, Mahmood R, Hewitt S, Durteste M, R E Cartlidge M . Visual tests predict dementia risk in Parkinson disease. Neurol Clin Pract. 2020; 10(1):29-39. PMC: 7057066. DOI: 10.1212/CPJ.0000000000000719. View

Deal J, Goman A, Albert M, Arnold M, Burgard S, Chisolm T . Hearing treatment for reducing cognitive decline: Design and methods of the Aging and Cognitive Health Evaluation in Elders randomized controlled trial. Alzheimers Dement (N Y). 2018; 4:499-507. PMC: 6197326. DOI: 10.1016/j.trci.2018.08.007. View

Toner C, Reese B, Neargarder S, Riedel T, Gilmore G, Cronin-Golomb A . Vision-fair neuropsychological assessment in normal aging, Parkinson's disease and Alzheimer's disease. Psychol Aging. 2011; 27(3):785-90. PMC: 3360123. DOI: 10.1037/a0026368. View

Rolls E . The cingulate cortex and limbic systems for emotion, action, and memory. Brain Struct Funct. 2019; 224(9):3001-3018. PMC: 6875144. DOI: 10.1007/s00429-019-01945-2. View

Doty R . Olfactory dysfunction in Parkinson disease. Nat Rev Neurol. 2012; 8(6):329-39. DOI: 10.1038/nrneurol.2012.80. View

Kocagoncu E, Klimovich-Gray A, Hughes L, Rowe J . Evidence and implications of abnormal predictive coding in dementia. Brain. 2021; 144(11):3311-3321. PMC: 8677549. DOI: 10.1093/brain/awab254. View

Parker T, Cash D, Lane C, Lu K, Malone I, Nicholas J . Pure tone audiometry and cerebral pathology in healthy older adults. J Neurol Neurosurg Psychiatry. 2019; 91(2):172-176. PMC: 6996095. DOI: 10.1136/jnnp-2019-321897. View

10.

Martorell A, Paulson A, Suk H, Abdurrob F, Drummond G, Guan W . Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Cell. 2019; 177(2):256-271.e22. PMC: 6774262. DOI: 10.1016/j.cell.2019.02.014. View

11.

Nathan B, Yost J, Litherland M, Struble R, Switzer P . Olfactory function in apoE knockout mice. Behav Brain Res. 2004; 150(1-2):1-7. DOI: 10.1016/S0166-4328(03)00219-5. View

12.

Jack Jr C, Bennett D, Blennow K, Carrillo M, Dunn B, Budd Haeberlein S . NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018; 14(4):535-562. PMC: 5958625. DOI: 10.1016/j.jalz.2018.02.018. View

13.

Dibattista M, Pifferi S, Menini A, Reisert J . Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?. Front Neurosci. 2020; 14:440. PMC: 7248389. DOI: 10.3389/fnins.2020.00440. View

14.

Griffiths T, Lad M, Kumar S, Holmes E, McMurray B, Maguire E . How Can Hearing Loss Cause Dementia?. Neuron. 2020; 108(3):401-412. PMC: 7664986. DOI: 10.1016/j.neuron.2020.08.003. View

15.

Devanand D, Lee S, Luchsinger J, Andrews H, Goldberg T, Huey E . Intact global cognitive and olfactory ability predicts lack of transition to dementia. Alzheimers Dement. 2019; 16(2):326-334. PMC: 7007828. DOI: 10.1016/j.jalz.2019.08.200. View

16.

Ikram M, Cheung C, Wong T, Chen C . Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2012; 83(9):917-22. DOI: 10.1136/jnnp-2011-301628. View

17.

Sarant J, Harris D, Busby P, Maruff P, Schembri A, Dowell R . The Effect of Cochlear Implants on Cognitive Function in Older Adults: Initial Baseline and 18-Month Follow Up Results for a Prospective International Longitudinal Study. Front Neurosci. 2019; 13:789. PMC: 6687844. DOI: 10.3389/fnins.2019.00789. View

18.

Flanigan P, Khosravi M, Leverenz J, Tousi B . Color Vision Impairment Differentiates Alzheimer Dementia From Dementia With Lewy Bodies. J Geriatr Psychiatry Neurol. 2018; 31(2):97-102. DOI: 10.1177/0891988718767579. View

19.

Wheeler P, Murphy C . Olfactory Measures as Predictors of Conversion to Mild Cognitive Impairment and Alzheimer's Disease. Brain Sci. 2021; 11(11). PMC: 8615615. DOI: 10.3390/brainsci11111391. View

20.

Sachdev P, Kalaria R, OBrien J, Skoog I, Alladi S, Black S . Diagnostic criteria for vascular cognitive disorders: a VASCOG statement. Alzheimer Dis Assoc Disord. 2014; 28(3):206-18. PMC: 4139434. DOI: 10.1097/WAD.0000000000000034. View