The Endoplasmic Reticulum Stress Response in Prostate Cancer

Overview

Journal Nat Rev Urol

Specialty Urology

Date 2022 Sep 28

PMID 36168057

Authors

Claire M de la Calle

Kevin Shee

Heiko Yang

Peter E Lonergan

Hao G Nguyen

Affiliations

Soon will be listed here.

Abstract

In order to proliferate in unfavourable conditions, cancer cells can take advantage of the naturally occurring endoplasmic reticulum-associated unfolded protein response (UPR) via three highly conserved signalling arms: IRE1α, PERK and ATF6. All three arms of the UPR have key roles in every step of tumour progression: from cancer initiation to tumour growth, invasion, metastasis and resistance to therapy. At present, no cure for metastatic prostate cancer exists, as targeting the androgen receptor eventually results in treatment resistance. New research has uncovered an important role for the UPR in prostate cancer tumorigenesis and crosstalk between the UPR and androgen receptor signalling pathways. With an improved understanding of the mechanisms by which cancer cells exploit the endoplasmic reticulum stress response, targetable points of vulnerability can be uncovered.

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