IgA Levels Among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study

Overview

Journal Eur J Dent

Publisher Thieme

Specialty Dentistry

Date 2022 Sep 27

PMID 36167319

Authors

Pooja Palwankar

Saumya Jain

Ruchi Pandey

Shakila Mahesh

Affiliations

Soon will be listed here.

Abstract

Objectives: To estimate gingival crevicular immunoglobulin A(IgA) using enzyme-linked immunosorbent assay (ELISA) among type II diabetic patients with periodontitis.

Materials And Methods: A non-randomized study was done of 40 periodontitis subjects with a mean age of 50 years and were recruited into two groups, Group A (Type II controlled diabetics with HbA1c < 7%) and Group B (non-diabetics with HbA1c between 4 and 6%). Both the groups underwent nonsurgical periodontal therapy (NSPT). The clinical parameters were recorded at baseline, 1, and 3 months. GCF sample was collected for the estimation of crevicular IgA at baseline and at 3 months.

Statistical Analysis: Results were analyzed using parametric tests paired -test and Student's -test for every assessment point. The level of significance was set at < 0.05.

Results: Difference in IgA levels and clinical parameters was seen between diabetic and non-diabetic groups, which was statistically significant.

Conclusion: Changes in crevicular IgA levels in patients with diabetic periodontitis can be used as a novel biomarker in assessing the inflammatory status.

Citing Articles

Key biomarkers in type 2 diabetes patients: A systematic review.

Le T, Bright R, Truong V, Li J, Juneja R, Vasilev K Diabetes Obes Metab. 2024; 27(1):7-22.

PMID: 39355932 PMC: 11618249. DOI: 10.1111/dom.15991.

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