Enhanced in Vitro IgM Rheumatoid Factor Synthesis in Seropositive Rheumatoid Arthritis Families

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 1987 Jan 1

PMID 3616388

Citations 3

Authors

G S Alarcon

B O Barger

R C Go

R T Acton

R E Schrohenloher

W J Koopman

Affiliations

Soon will be listed here.

Abstract

We studied the patterns of in vitro IgM RF production by peripheral blood mononuclear leukocytes (MNL) in first- and second-degree relatives and non-blood relatives of 14 RA patients. In all these included 25 individuals with RA (14 probands, 11 other affected members), 88 non-affected first- and second-degree relatives and 15 non-affected non-blood relatives. In vitro production of IgM RF and IgM by MNL from RA patients was similar to what we and others have previously described. Spontaneous production of IgM RF was demonstrated by MNL from some RA patients and the ratio of IgM RF to total IgM was higher for patients than controls. The non-blood relatives failed to demonstrate spontaneous in vitro IgM RF production. In contrast, MNL from approximately 16% of non-affected blood relatives spontaneously produced IgM RF. Spontaneous IgM RF production in this group did not correlate with HLA-DR3 or HLA-DR4 and was found in Caucasoids. American blacks, simplex (one affected individual), and multiplex (more than one affected individual) families. Linkage analysis using either a recessive or dominant model of inheritance failed to detect linkage among affected and non-affected family members.

Citing Articles

A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA.

Kolfenbach J, Deane K, Derber L, ODonnell C, Weisman M, Buckner J Arthritis Rheum. 2009; 61(12):1735-42.

PMID: 19950324 PMC: 2795101. DOI: 10.1002/art.24833.

Occurrence of a rheumatoid factor cross-reactive kappa light-chain idiotope in rheumatoid arthritis families.

Schrohenloher R, Alarcon G, Koopman W Rheumatol Int. 1990; 10(5):211-5.

PMID: 2127469 DOI: 10.1007/BF02274835.

Production of IgM rheumatoid factor by normal lymphocytes after stimulation with preparations containing IgM rheumatoid factor from patients with juvenile arthritis.

Nesher G, Moore T, Osborn T, Dorner R Ann Rheum Dis. 1991; 50(3):142-6.

PMID: 2015007 PMC: 1004362. DOI: 10.1136/ard.50.3.142.

References

Cleland L, Bell D, Willans M, Saurino B . Familial lupus. Family studies of HLA and serologic findings. Arthritis Rheum. 1978; 21(2):183-91. DOI: 10.1002/art.1780210202. View

Go R, Alarcon G, Acton R, Koopman W, Vittor V, Barger B . Analyses of HLA linkage in white families with multiple cases of seropositive rheumatoid arthritis. Arthritis Rheum. 1987; 30(10):1115-23. DOI: 10.1002/art.1780301005. View

PLOTZ C, SINGER J . The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956; 21(6):888-92. View

Arnett F, Reveille J, Wilson R, Provost T, Bias W . Systemic lupus erythematosus: current state of the genetic hypothesis. Semin Arthritis Rheum. 1984; 14(1):24-35. DOI: 10.1016/0049-0172(84)90006-4. View

Alarcon G, Koopman W, Schrohenloher R . In vitro synthesis of IgM and IgM rheumatoid factor in seronegative arthritides. Rheumatol Int. 1984; 4(2):49-53. DOI: 10.1007/BF00541196. View

Alarcon G, Koopman W, Schrohenloher R . Differential patterns of in vitro IgM rheumatoid factor synthesis in seronegative and seropositive rheumatoid arthritis. Arthritis Rheum. 1982; 25(2):150-5. DOI: 10.1002/art.1780250206. View

Grennan D, Dyer P, Clague R, Dodds W, Smeaton I, Harris R . Family studies in RA - the importance of HLA-DR4 and of genes for autoimmune thyroid disease. J Rheumatol. 1983; 10(4):584-9. View

Cats A, Hazevoet H . Significance of positive tests for rheumatoid factor in the prognosis of rheumatoid arthritis. A follow-up study. Ann Rheum Dis. 1970; 29(3):254-60. PMC: 1031259. DOI: 10.1136/ard.29.3.254. View

Koopman W, Schrohenloher R . In vitro synthesis of IgM rheumatoid factor by lymphocytes from healthy adults. J Immunol. 1980; 125(2):934-9. View

10.

Strom H, Moller E . HLA and rheumatoid arthritis. A study of five families. Tissue Antigens. 1981; 18(2):92-100. DOI: 10.1111/j.1399-0039.1981.tb01370.x. View

11.

Morton N . Sequential tests for the detection of linkage. Am J Hum Genet. 1955; 7(3):277-318. PMC: 1716611. View

12.

MASI A, Kaplan S, Feigenbaum S, Chandler R . Prospective study of the early course of rheumatoid arthritis in young adults: comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome. Semin Arthritis Rheum. 1976; 4(4):299-326. DOI: 10.1016/0049-0172(76)90013-5. View

13.

Lawrence J . Rheumatoid factors in families. Semin Arthritis Rheum. 1973; 3(2):177-88. DOI: 10.1016/0049-0172(73)90010-3. View

14.

Slaughter L, Carson D, JENSEN F, Holbrook T, Vaughan J . In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects. J Exp Med. 1978; 148(5):1429-34. PMC: 2185048. DOI: 10.1084/jem.148.5.1429. View

15.

del Junco D, Luthra H, Annegers J, WORTHINGTON J, Kurland L . The familial aggregation of rheumatoid arthritis and its relationship to the HLA-DR4 association. Am J Epidemiol. 1984; 119(5):813-29. DOI: 10.1093/oxfordjournals.aje.a113802. View

16.

Vaughan J, Chihara T, Moore T, Robbins D, Tanimoto K, Johnson J . Rheumatoid factor-producing cells detected by direct hemolytic plaque assay. J Clin Invest. 1976; 58(4):933-41. PMC: 333256. DOI: 10.1172/JCI108546. View

17.

Koopman W, Schrohenloher R . A sensitive radioimmunoassay for quantitation of IgM rheumatoid factor. Arthritis Rheum. 1980; 23(3):302-8. DOI: 10.1002/art.1780230306. View

18.

Hochberg M . Adult and juvenile rheumatoid arthritis: current epidemiologic concepts. Epidemiol Rev. 1981; 3:27-44. DOI: 10.1093/oxfordjournals.epirev.a036238. View

19.

Siegel M, Lee S, WIDELOCK D, Gwon N, Kravitz H . A comparative family study of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 1965; 273(17):893-7. DOI: 10.1056/NEJM196510212731702. View

20.

Bennett H, Burch T . The distribution of rheumatoid factor and rheumatoid arthritis in the families of Blackfeet and Pima Indians. Arthritis Rheum. 1968; 11(4):546-53. DOI: 10.1002/art.1780110404. View