GDF15 : A Modulator of Immunity and a Predictive Biomarker of Cardiovascular Events : A Strategy In COVID-19

Overview

Journal Ann Cardiol Angeiol (Paris)

Publisher Elsevier

Date 2022 Sep 26

PMID 36163282

Authors

Luc Rochette

Geoffrey Dogon

Eve Rigal

Marianne Zeller

Catherine Vergely

Yves Cottin

Affiliations

Soon will be listed here.

Abstract

In the recently published manuscript entitled "GDF15 a rising modulator of immunity and a strategy in Coronavirus disease 2019 (COVID-19) in relationship with iron metabolism" and we examined the potential properties of Growth and differentiation factor 15 (GDF15) as an emerging modulator of immunity in COVID-19. We commented new aspects of the biology of GDF15 and investigated the potential value of GDF15 as a biomarker. Is GDF15 a biomarker of the inflammatory process and oxidative stress state? Recently, it was reported that 1500 clinical trials related to COVID-19 have been registered, but none have yet found an optimal strategy. In these conditions, more clinical studies are needed before any of these agents can be considered antiviral agents.

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