A Neglected Neurodegenerative Disease: Adult-onset Globoid Cell Leukodystrophy

Overview

Journal Front Neurosci

Date 2022 Sep 26

PMID 36161165

Authors

Guode Wu

Zhenhua Li

Jing Li

Xin Li

Manxia Wang

Jing Zhang

Guangyao Liu

Pengfei Zhang

Affiliations

Soon will be listed here.

Abstract

Globoid cell leukodystrophy (GLD), or Krabbe disease (KD) is a rare neurodegenerative disease, and adult-onset GLD is more even neglected by clinicians. This review provides detailed discussions of the serum enzymes, genes, clinical manifestations, neuroimaging features, and therapies of GLD, with particular emphasis on the characteristics of adult-onset GLD, in an attempt to provide clinicians with in-depth insights into this disease.

Citing Articles

Late-Onset Krabbe Disease: Case Report of Two Patients in a Chinese Family and Literature Review.

Sun Y, Zheng J, He L, Li X, Liu W, Wu J Mol Genet Genomic Med. 2025; 13(2):e70065.

PMID: 39878400 PMC: 11775926. DOI: 10.1002/mgg3.70065.

Globoid Cell Leukodystrophy (Krabbe Disease): An Update.

Maghazachi A Immunotargets Ther. 2023; 12:105-111.

PMID: 37928748 PMC: 10625317. DOI: 10.2147/ITT.S424622.

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