ELA-11 Protects the Heart Against Oxidative Stress Injury Induced Apoptosis Through ERK/MAPK and PI3K/AKT Signaling Pathways

Overview

Journal Front Pharmacol

Date 2022 Sep 26

PMID 36160397

Authors

Xuejun Wang

Li Zhang

Mengwen Feng

Zhongqing Xu

Zijie Cheng

Lingmei Qian

Affiliations

Soon will be listed here.

Abstract

Increasing evidence revealed that apoptosis and oxidative stress injury were associated with the pathophysiology of doxorubicin (DOX)-induced myocardial injury. ELABELA (ELA) is a newly identified peptide with 32 amino acids, can reduce hypertension with exogenous infusion. However, the effect of 11-residue furn-cleaved fragment (ELA-11) is still unclear. We first administrated ELA-11 in DOX-injured mice and measured the cardiac function and investigated the effect of ELA-11 . We found that ELA-11 alleviated heart injury induced by DOX and inhibited cardiac tissues from apoptosis. , ELA-11 regulated the sensitivity towards apoptosis induced by oxidative stress with DOX treatment through PI3K/AKT and ERK/MAPK signaling pathway. Similarly, ELA-11 inhibited oxidative stress-induced apoptosis in cobalt chloride (CoCl)-injured cardiomyocytes. Moreover, ELA-11 protected cardiomyocyte by interacting with Apelin receptor (APJ) by using 4-oxo-6-((pyrimidin-2-ylthio) methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221). Hence, our results indicated a protective role of ELA-11 in oxidative stress-induced apoptosis in DOX-induced myocardial injury.

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