The Relationship Between Hemoglobin and Triglycerides in Moyamoya Disease: A Cross-sectional Study

Overview

Journal Front Neurol

Specialty Neurology

Date 2022 Sep 26

PMID 36158949

Authors

Yu Su

Genhua Li

Huihui Zhao

Song Feng

Yan Lu

Jilan Liu

Chao Chen

Feng Jin

Affiliations

Soon will be listed here.

Abstract

Hemoglobin (Hb) and lipid metabolism are critical in the pathophysiology of moyamoya disease (MMD), and Hb and triglycerides (TGs) both play roles in the development of cerebrovascular illness. However, there is little evidence of a link between Hb and TGs in patients with MMD. This study aimed to determine the association between Hb and TGs in patients who had recently been diagnosed with MMD. From March 2013 to December 2018, 337 patients clinically diagnosed with MMD were admitted to our hospital. Among these, 235 were selected for analysis in this retrospective, cross-sectional study. Each patient's clinical features were documented. For analysis, we used univariate analysis, smoothed-curve fitting, and multivariable, piecewise linear regression. Overall, the mean±standard deviation patient age was 48.14 ± 11.24 years, 44.68% were men, and the mean Hb concentration was 135.72 ± 18.99 g/L. After controlling for relevant confounders, smoothed-curve fitting revealed a nonlinear association between the Hb and TG concentrations ( = 0.0448). When the Hb concentration was below 141 g/L, multivariate piecewise linear regression analysis revealed a significant association between the Hb and TG concentrations [β: 0.01, 95% confidence interval (CI): 0.00, 0.01; = 0.0182], although the association disappeared above this threshold (β:-0.00, 95% CI:-0.01, 0.01; = 0.4429). In individuals newly diagnosed with MMD, there is a significant correlation between Hb and TGs, which may be connected to MMD pathogenesis.

Citing Articles

Correlation between inflammatory marker and lipid metabolism in patients with uterine leiomyomas.

Duan Y, Guo L, Peng Y, Shi X, Zhao Y, Liu K Front Med (Lausanne). 2023; 10:1124697.

PMID: 37206470 PMC: 10189017. DOI: 10.3389/fmed.2023.1124697.

References

Saucedo C, Courtois E, Wade Z, Kelley M, Kheradbin N, Barrett D . Transcranial laser stimulation: Mitochondrial and cerebrovascular effects in younger and older healthy adults. Brain Stimul. 2021; 14(2):440-449. DOI: 10.1016/j.brs.2021.02.011. View

Bale G, Mitra S, De Roever I, Sokolska M, Price D, Bainbridge A . Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury. J Cereb Blood Flow Metab. 2018; 39(10):2035-2047. PMC: 6775592. DOI: 10.1177/0271678X18777928. View

Tahir A, Martinez P, Ahmad F, Fisher-Hoch S, McCormick J, Gay J . An evaluation of lipid profile and pro-inflammatory cytokines as determinants of cardiovascular disease in those with diabetes: a study on a Mexican American cohort. Sci Rep. 2021; 11(1):2435. PMC: 7844256. DOI: 10.1038/s41598-021-81730-6. View

Mineharu Y, Miyamoto S . RNF213 and GUCY1A3 in Moyamoya Disease: Key Regulators of Metabolism, Inflammation, and Vascular Stability. Front Neurol. 2021; 12:687088. PMC: 8350054. DOI: 10.3389/fneur.2021.687088. View

Ma W, Cui C, Feng S, Li G, Han G, Hu Y . Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study. Biomed Res Int. 2019; 2019:9792412. PMC: 6634014. DOI: 10.1155/2019/9792412. View

Bachi A, Barros M, Vieira R, Rocha G, de Andrade P, Victorino A . Combined Exercise Training Performed by Elderly Women Reduces Redox Indexes and Proinflammatory Cytokines Related to Atherogenesis. Oxid Med Cell Longev. 2019; 2019:6469213. PMC: 6701434. DOI: 10.1155/2019/6469213. View

Ahankari A, Kabra P, Tata L, Hayter M, Fogarty A . Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: a cross-sectional study. Trop Med Int Health. 2020; 26(3):327-334. DOI: 10.1111/tmi.13524. View

Ge P, Ye X, Zhang Q, Liu X, Deng X, Zhao M . Clinical features, surgical treatment, and outcome of intracranial aneurysms associated with moyamoya disease. J Clin Neurosci. 2020; 80:274-279. DOI: 10.1016/j.jocn.2020.09.006. View

Fuentes A, Chiu R, Mehta A . Disparities in the symptomatic presentation of Moyamoya disease in the United States: A nationwide all-payer analysis. J Clin Neurosci. 2021; 87:92-96. DOI: 10.1016/j.jocn.2021.02.019. View

10.

Kumar Y, Dogra A, Kaushik A, Kumar S . Progressive evaluation in spectroscopic sensors for non-invasive blood haemoglobin analysis-a review. Physiol Meas. 2021; 43(2). DOI: 10.1088/1361-6579/ac41b7. View

11.

Zhang S, Shu Y, Li W, Wei C, Deng A, Cheng Y . High haemoglobin levels and mortality in males with intracerebral haemorrhage: a retrospective cohort study. BMJ Open. 2022; 12(1):e048108. PMC: 8728416. DOI: 10.1136/bmjopen-2020-048108. View

12.

Liu Q, Wang X, Wang Y, Wang C, Zhao X, Liu L . Both Ends of Values in the Hemoglobin Spectrum Are Associated with Adverse Stroke Outcomes. Cerebrovasc Dis. 2021; 51(1):36-44. DOI: 10.1159/000517868. View

13.

Kopcekova J, Lenartova P, Mrazova J, Gazarova M, Habanova M, Jancichova K . The relationship between seeds consumption, lipid profile and body mass index among patients with cardiovascular diseases. Rocz Panstw Zakl Hig. 2021; 72(2):145-153. DOI: 10.32394/rpzh.2021.0159. View

14.

Cas M, Carrozzini T, Pollaci G, Potenza A, Nava S, Canavero I . Plasma Lipid Profiling Contributes to Untangle the Complexity of Moyamoya Arteriopathy. Int J Mol Sci. 2021; 22(24). PMC: 8708587. DOI: 10.3390/ijms222413410. View

15.

Hadjistassou C, Moyle K, Ventikos Y . Reproducing the Hemoglobin Saturation Profile, a Marker of the Blood Oxygenation Level Dependent (BOLD) fMRI Effect, at the Microscopic Level. PLoS One. 2016; 11(3):e0149935. PMC: 4777512. DOI: 10.1371/journal.pone.0149935. View

16.

Agyemang A, Kvist S, Brinkman N, Gentinetta T, Illa M, Ortenlof N . Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture. J Neuroinflammation. 2021; 18(1):42. PMC: 7879625. DOI: 10.1186/s12974-020-02052-4. View

17.

Kitagami M, Yasuda R, Toma N, Shiba M, Nampei M, Yamamoto Y . Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels. J Stroke Cerebrovasc Dis. 2017; 26(8):1793-1800. DOI: 10.1016/j.jstrokecerebrovasdis.2017.04.010. View

18.

Karling P, Lundgren D, Eklof V, Palmqvist R, Hultdin J . Improved monitoring of inflammatory activity in patients with ulcerative colitis by combination of faecal tests for haemoglobin and calprotectin. Scand J Clin Lab Invest. 2019; 79(5):341-346. DOI: 10.1080/00365513.2019.1622148. View

19.

Akiyama Y, Mikami T, Mikuni N . Deep Learning-Based Approach for the Diagnosis of Moyamoya Disease. J Stroke Cerebrovasc Dis. 2020; 29(12):105322. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105322. View

20.

Chang J, Lee J, Kim B, Kim J, Lee J, Cha J . Influence of Hemoglobin Concentration on Stroke Recurrence and Composite Vascular Events. Stroke. 2020; 51(4):1309-1312. DOI: 10.1161/STROKEAHA.119.028058. View