The Association Between Caffeine Exposure During Pregnancy and Risk of Gestational Hypertension/preeclampsia: A Meta-analysis and Systematical Review

Overview

Journal J Obstet Gynaecol Res

Specialty Gynecology & Obstetrics

Date 2022 Sep 26

PMID 36156331

Authors

Bangsheng Chen

Mengting Zhang

Yujing He

Yuexiu Si

Yetan Shi

Ke Jiang

Jingyi Shen

Jiaze Hong

Saisai Ni

Affiliations

Soon will be listed here.

Abstract

Background: The potential effect of caffeine exposure during pregnancy on gestational hypertension (GH)/preeclampsia has attracted attention but remains unclear.

Methods: A systematic literature search of PubMed, Embase, and Cochrane Library databases was performed until March 2022. Observational studies assessing the association between caffeine exposure during pregnancy and the risk of GH/preeclampsia were included. The study protocol was registered in PROSPERO: CRD42022322387.

Results: Ten studies involving 114 984 pregnant women (2548 diagnosed with GH and 2473 diagnosed with preeclampsia) were included. Comparing caffeine exposure with noncaffeine exposure, no significant association was found between caffeine exposure during pregnancy and the risk of GH (odds ratio [OR] = 0.99, 95% confidence interval [CI]: 0.90-1.08, p = 0.800) and preeclampsia (OR = 1.13, 95% CI: 0.97-1.31, p = 0.114). Subgroup analyses comparing low to moderate doses with no/lowest doses showed that caffeine exposure during pregnancy was not significant associated with GH (OR = 1.00, p = 0.987) or preeclampsia (OR = 1.03, p = 0.648). Besides, subgroup analyses comparing high doses with no/lowest doses showed that caffeine exposure during pregnancy was not significant associated with GH (OR = 1.06, p = 0.623) or preeclampsia (OR = 1.18, p = 0.192).

Conclusion: This study found that caffeine exposure during pregnancy was not significantly associated with the risk of GH/preeclampsia.

Citing Articles

The association between antenatal coffee consumption and preeclampsia: a systematic review and meta-analysis.

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The Association between Antenatal Tea Drinking and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.

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