Response to the Letter to the Editor "The Apparent Beneficial Effect of L-arginine for Stroke-like Lesions Can Be Accidental" by Josef Finsterer and Sinda Zarrouk

Overview

Journal Neurohospitalist

Publisher Sage Publications

Date 2022 Sep 23

PMID 36147768

Authors

Ghalia Al Yazidi

Jaap Mulder

Christoph Licht

Elizabeth Harvey

Ingrid Tein

Affiliations

Soon will be listed here.

References

Tein I . Role of carnitine and fatty acid oxidation and its defects in infantile epilepsy. J Child Neurol. 2003; 17 Suppl 3:3S57-82; discussion 3S82-3. View

Mizukami K, Sasaki M, Suzuki T, Shiraishi H, Koizumi J, Ohkoshi N . Central nervous system changes in mitochondrial encephalomyopathy: light and electron microscopic study. Acta Neuropathol. 1992; 83(4):449-52. DOI: 10.1007/BF00713541. View

Kodaka R, ITAGAKI Y, Matsumoto M, Nagai T, Okada S . A transcranial doppler ultrasonography study of cerebrovascular CO2 reactivity in mitochondrial encephalomyopathy. Stroke. 1996; 27(8):1350-3. DOI: 10.1161/01.str.27.8.1350. View

Iizuka T, Sakai F, Ide T, Miyakawa S, Sato M, Yoshii S . Regional cerebral blood flow and cerebrovascular reactivity during chronic stage of stroke-like episodes in MELAS -- implication of neurovascular cellular mechanism. J Neurol Sci. 2007; 257(1-2):126-38. DOI: 10.1016/j.jns.2007.01.040. View

Siddiq I, Widjaja E, Tein I . Clinical and radiologic reversal of stroke-like episodes in MELAS with high-dose L-arginine. Neurology. 2015; 85(2):197-8. PMC: 4515037. DOI: 10.1212/WNL.0000000000001726. View

Salsaa M, Pereira B, Liu J, Yu W, Jadhav S, Huttemann M . Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae. Sci Rep. 2020; 10(1):11785. PMC: 7367371. DOI: 10.1038/s41598-020-68725-5. View

Koga Y, Povalko N, Nishioka J, Katayama K, Kakimoto N, Matsuishi T . MELAS and L-arginine therapy: pathophysiology of stroke-like episodes. Ann N Y Acad Sci. 2010; 1201:104-10. DOI: 10.1111/j.1749-6632.2010.05624.x. View

Gropen T, Prohovnik I, Tatemichi T, Hirano M . Cerebral hyperemia in MELAS. Stroke. 1994; 25(9):1873-6. DOI: 10.1161/01.str.25.9.1873. View

Rodan L, Poublanc J, Fisher J, Sobczyk O, Wong T, Hlasny E . Cerebral hyperperfusion and decreased cerebrovascular reactivity correlate with neurologic disease severity in MELAS. Mitochondrion. 2015; 22:66-74. DOI: 10.1016/j.mito.2015.03.002. View

10.

Rodan L, Poublanc J, Fisher J, Sobczyk O, Mikulis D, Tein I . L-arginine effects on cerebrovascular reactivity, perfusion and neurovascular coupling in MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) syndrome. PLoS One. 2020; 15(9):e0238224. PMC: 7470264. DOI: 10.1371/journal.pone.0238224. View

11.

Gilchrist J, Sikirica M, Stopa E, Shanske S . Adult-onset MELAS. Evidence for involvement of neurons as well as cerebral vasculature in strokelike episodes. Stroke. 1996; 27(8):1420-3. DOI: 10.1161/01.str.27.8.1420. View

12.

Nariai T, Ohno K, Akimoto H, Ohta Y, Nagaoka T, Hirakawa K . Cerebral blood flow, vascular response and metabolism in patients with MELAS syndrome--xenon CT and PET study. Keio J Med. 2000; 49 Suppl 1:A68-70. View

13.

Koga Y, Povalko N, Nishioka J, Katayama K, Yatsuga S, Matsuishi T . Molecular pathology of MELAS and L-arginine effects. Biochim Biophys Acta. 2011; 1820(5):608-14. DOI: 10.1016/j.bbagen.2011.09.005. View

14.

Tein I, DiMauro S, Xie Z, De Vivo D . Valproic acid impairs carnitine uptake in cultured human skin fibroblasts. An in vitro model for the pathogenesis of valproic acid-associated carnitine deficiency. Pediatr Res. 1993; 34(3):281-7. DOI: 10.1203/00006450-199309000-00008. View

15.

Ito H, Mori K, Kagami S . Neuroimaging of stroke-like episodes in MELAS. Brain Dev. 2010; 33(4):283-8. DOI: 10.1016/j.braindev.2010.06.010. View

16.

Tein I, Xie Z . Reversal of valproic acid-associated impairment of carnitine uptake in cultured human skin fibroblasts. Biochem Biophys Res Commun. 1994; 204(2):753-8. DOI: 10.1006/bbrc.1994.2523. View

17.

Nishioka J, Akita Y, Yatsuga S, Katayama K, Matsuishi T, Ishibashi M . Inappropriate intracranial hemodynamics in the natural course of MELAS. Brain Dev. 2007; 30(2):100-5. DOI: 10.1016/j.braindev.2007.06.008. View

18.

De Vivo D, Bohan T, Coulter D, Dreifuss F, Greenwood R, Nordli Jr D . L-carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia. 1998; 39(11):1216-25. DOI: 10.1111/j.1528-1157.1998.tb01315.x. View

19.

Molnar M, Valikovics A, Molnar S, Tron L, Dioszeghy P, Mechler F . Cerebral blood flow and glucose metabolism in mitochondrial disorders. Neurology. 2000; 55(4):544-8. DOI: 10.1212/wnl.55.4.544. View

20.

Morris Jr S . Arginine metabolism: boundaries of our knowledge. J Nutr. 2007; 137(6 Suppl 2):1602S-1609S. DOI: 10.1093/jn/137.6.1602S. View