Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2022 Sep 23

PMID 36147481

Authors

Ye Zhang

Ran Guo

Shan-Shan Wang

Xiao-You Jiang

Hong-Yan Cui

Yang Guo

Xiao-Yu Song

Qi-Qiang Guo

Liu Cao

Affiliations

Soon will be listed here.

Abstract

It is emerging that autophagy-related proteins regulate the adaptive response to DNA damage in maintaining genome stability at multiple pathways. Here, we discuss recent insights into how autophagy-related proteins participate in DNA damage repair processes, influence chromosomal instability, and regulate the cell cycle through autophagy-dependent and independent actions. There is increasing awareness of the importance of these pathways mediated by autophagy-related proteins to DNA damage response (DDR), and disturbances in these regulatory connections may be linked to genomic instability participated in various human diseases, such as cancer and aging.

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