Initial Exploration of the Discriminatory Ability of the PetPace Collar to Detect Differences in Activity and Physiological Variables Between Healthy and Osteoarthritic Dogs

Overview

Journal Front Pain Res (Lausanne)

Date 2022 Sep 23

PMID 36147035

Authors

Avery Rowlison de Ortiz

Beatriz Belda

Jon Hash

Masataka Enomoto

James Robertson

B Duncan X Lascelles

Affiliations

Soon will be listed here.

Abstract

Background: Accelerometry has been used to evaluate activity in dogs with osteoarthritis (OA) pain, especially in relation to effect of treatment; however no studies have compared accelerometry-measured activity in dogs with OA-pain and healthy dogs. The aims of this study were to (1) compare activity output from the PetPace collar with the validated Actical monitor and (2) determine if PetPace collar outputs (overall activity, activity levels, body position, and vital signs) differed between healthy dogs and dogs with OA-pain.

Methods: This was an observational, non-interventional study in healthy dogs and dogs with OA-pain. All dogs were outfitted with the PetPace collar and the Actical monitor simultaneously for 14 days. Output from these devices was compared (correlations), and output from the PetPace device was used to explore differences between groups across the activity and vital sign outputs (including calculated heart rate variability indices).

Results: There was moderate correlation between the PetPace collar and Actical monitor output ( = 0.56, < 0.001). Using data generated by the PetPace collar, OA-pain dogs had lower overall activity counts and spent less time standing than healthy dogs. Healthy dogs spent more time at higher activity levels than OA-pain dogs. Certain heart rate variability indices in OA-pain dogs were lower than in healthy dogs.

Conclusions And Clinical Relevance: The results of this study suggest that the PetPace collar can detect differences between healthy dogs and those with OA-pain, and that OA-pain negatively impacts overall activity levels in dogs, and especially higher intensity activity.

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References

Wernham B, Trumpatori B, Hash J, Lipsett J, Davidson G, Wackerow P . Dose reduction of meloxicam in dogs with osteoarthritis-associated pain and impaired mobility. J Vet Intern Med. 2011; 25(6):1298-305. DOI: 10.1111/j.1939-1676.2011.00825.x. View

Schulz K, Altman D, Moher D . CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010; 340:c332. PMC: 2844940. DOI: 10.1136/bmj.c332. View

Johnston S . Osteoarthritis. Joint anatomy, physiology, and pathobiology. Vet Clin North Am Small Anim Pract. 1997; 27(4):699-723. DOI: 10.1016/s0195-5616(97)50076-3. View

Evrengul H, Dursunoglu D, Cobankara V, Polat B, Seleci D, Kabukcu S . Heart rate variability in patients with rheumatoid arthritis. Rheumatol Int. 2003; 24(4):198-202. DOI: 10.1007/s00296-003-0357-5. View

Conzemius M, Torres B, Muir P, Evans R, Krotscheck U, Budsberg S . Best practices for measuring and reporting ground reaction forces in dogs. Vet Surg. 2022; 51(3):385-396. DOI: 10.1111/vsu.13772. View

Hezzell M, Sleeper M, Ferrari J, Arndt J . Sample Size Determination for Evaluation of Time Domain Heart Rate Variability Indices in Canine Lameness. J Am Anim Hosp Assoc. 2018; 54(5):235-238. DOI: 10.5326/JAAHA-MS-6533. View

Bogucki S, Noszczyk-Nowak A . Short-term heart rate variability (HRV) in healthy dogs. Pol J Vet Sci. 2015; 18(2):307-12. DOI: 10.1515/pjvs-2015-0040. View

Wormald D, Lawrence A, Carter G, Fisher A . Reduced heart rate variability in pet dogs affected by anxiety-related behaviour problems. Physiol Behav. 2016; 168:122-127. DOI: 10.1016/j.physbeh.2016.11.003. View

Kimura S, Yamaguchi S, Ono Y, Matsuura Y, Sato Y, Akagi R . Decreased physical activity in patients with ankle osteoarthritis. A case-control study comparing daily step counts. Foot Ankle Surg. 2021; 28(1):66-71. DOI: 10.1016/j.fas.2021.01.011. View

10.

Azevedo M, Araujo C, Reichert F, Siqueira F, Cozzensa da Silva M, Hallal P . Gender differences in leisure-time physical activity. Int J Public Health. 2007; 52(1):8-15. PMC: 2778720. DOI: 10.1007/s00038-006-5062-1. View

11.

Muller C, Enomoto M, Buono A, Steiner J, Lascelles B . Placebo-controlled pilot study of the effects of an eggshell membrane-based supplement on mobility and serum biomarkers in dogs with osteoarthritis. Vet J. 2019; 253:105379. DOI: 10.1016/j.tvjl.2019.105379. View

12.

Woods H, Li M, Patel U, Lascelles B, Samson D, Gruen M . A functional linear modeling approach to sleep-wake cycles in dogs. Sci Rep. 2020; 10(1):22233. PMC: 7747556. DOI: 10.1038/s41598-020-79274-2. View

13.

Farr J, Going S, Lohman T, Rankin L, Kasle S, Cornett M . Physical activity levels in patients with early knee osteoarthritis measured by accelerometry. Arthritis Rheum. 2008; 59(9):1229-36. PMC: 2595140. DOI: 10.1002/art.24007. View

14.

Brown D, Boston R, Coyne J, Farrar J . Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis. J Am Vet Med Assoc. 2009; 233(8):1278-83. PMC: 2896492. DOI: 10.2460/javma.233.8.1278. View

15.

Staud R . Heart rate variability as a biomarker of fibromyalgia syndrome. Fut Rheumatol. 2009; 3(5):475-483. PMC: 2772072. DOI: 10.2217/17460816.3.5.475. View

16.

Muller C, Gines J, Conzemius M, Meyers R, Lascelles B . Evaluation of the effect of signalment and owner-reported impairment level on accelerometer-measured changes in activity in osteoarthritic dogs receiving a non-steroidal anti-inflammatory. Vet J. 2018; 242:48-52. DOI: 10.1016/j.tvjl.2018.10.005. View

17.

Hansen B, Lascelles B, Keene B, Adams A, Thomson A . Evaluation of an accelerometer for at-home monitoring of spontaneous activity in dogs. Am J Vet Res. 2007; 68(5):468-75. DOI: 10.2460/ajvr.68.5.468. View

18.

Gay C, Guiguet-Auclair C, Mourgues C, Gerbaud L, Coudeyre E . Physical activity level and association with behavioral factors in knee osteoarthritis. Ann Phys Rehabil Med. 2018; 62(1):14-20. DOI: 10.1016/j.rehab.2018.09.005. View

19.

Waxman A, Robinson D, Evans R, Hulse D, Innes J, Conzemius M . Relationship between objective and subjective assessment of limb function in normal dogs with an experimentally induced lameness. Vet Surg. 2008; 37(3):241-6. DOI: 10.1111/j.1532-950X.2008.00372.x. View

20.

Vasseur P, Johnson A, Budsberg S, Lincoln J, Toombs J, Whitehair J . Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal anti-inflammatory drug, in the treatment of osteoarthritis in dogs. J Am Vet Med Assoc. 1995; 206(6):807-11. View