Chikungunya Virus Shedding in Semen: A Case Series

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2022 Sep 23

PMID 36146686

Authors

Ezequias B Martins

Fernanda de Bruycker-Nogueira

Cintia D S Rodrigues

Carolina C Santos

Simone A Sampaio

Allison A Fabri

Vinicius Guerra-Campos

Maria Angelica M Mares-Guia

Nieli R C Faria

Aline S Santos

Marcelle A S Pinto

Michele F B Silva

Isabella C V Moraes

Anielle Pina-Costa

Ana Maria B Filippis

Patricia Brasil

Guilherme A Calvet

Affiliations

Soon will be listed here.

Abstract

Background: Chikungunya is a viral disease that is transmitted by mosquitoes. It is characterized by an acute onset of fever and severe arthralgia.

Methods: We describe six cases of acute and post-acute chikungunya in which viral RNA was detected in semen.

Conclusions: The most prolonged detection period was 56 days after illness onset. We attempted to cultivate positive semen samples, but virus isolation was unsuccessful in all cases.

Citing Articles

Special Issue "Chikungunya Virus and Emerging Alphaviruses".

Pereira M, Franca R Viruses. 2023; 15(8).

PMID: 37632110 PMC: 10457814. DOI: 10.3390/v15081768.

References

Leparc-Goffart I, Nougairede A, Cassadou S, Prat C, de Lamballerie X . Chikungunya in the Americas. Lancet. 2014; 383(9916):514. DOI: 10.1016/S0140-6736(14)60185-9. View

Salam A, Horby P . The Breadth of Viruses in Human Semen. Emerg Infect Dis. 2017; 23(11):1922-1924. PMC: 5652425. DOI: 10.3201/eid2311.171049. View

Lanciotti R, Kosoy O, Laven J, Panella A, Velez J, Lambert A . Chikungunya virus in US travelers returning from India, 2006. Emerg Infect Dis. 2007; 13(5):764-7. PMC: 2738459. DOI: 10.3201/eid1305.070015. View

Atkinson B, Thorburn F, Petridou C, Bailey D, Hewson R, Simpson A . Presence and Persistence of Zika Virus RNA in Semen, United Kingdom, 2016. Emerg Infect Dis. 2016; 23(4):611-615. PMC: 5367426. DOI: 10.3201/eid2304.161692. View

Loayza Mafayle R, Morales-Betoulle M, Romero C, Cossaboom C, Whitmer S, Alvarez Aguilera C . Chapare Hemorrhagic Fever and Virus Detection in Rodents in Bolivia in 2019. N Engl J Med. 2022; 386(24):2283-2294. PMC: 10245337. DOI: 10.1056/NEJMoa2110339. View

Nunes M, Faria N, de Vasconcelos J, Golding N, Kraemer M, de Oliveira L . Emergence and potential for spread of Chikungunya virus in Brazil. BMC Med. 2015; 13:102. PMC: 4433093. DOI: 10.1186/s12916-015-0348-x. View

Lalle E, Colavita F, Iannetta M, Gebremeskel Tekle S, Carletti F, Scorzolini L . Prolonged detection of dengue virus RNA in the semen of a man returning from Thailand to Italy, January 2018. Euro Surveill. 2018; 23(18). PMC: 6053624. DOI: 10.2807/1560-7917.ES.2018.23.18.18-00197. View

Brunstein J . Freeze-thaw cycles and nucleic acid stability: what's safe for your samples?. MLO Med Lab Obs. 2015; 47(9):44-5. View

Wang R, Gornalusse G, Kim Y, Pandey U, Hladik F, Vojtech L . Potent Restriction of Sexual Zika Virus Infection by the Lipid Fraction of Extracellular Vesicles in Semen. Front Microbiol. 2020; 11:574054. PMC: 7550675. DOI: 10.3389/fmicb.2020.574054. View

10.

Brainard J, Pond K, Hooper L, Edmunds K, Hunter P . Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review. PLoS Negl Trop Dis. 2016; 10(2):e0004475. PMC: 4771830. DOI: 10.1371/journal.pntd.0004475. View

11.

Martins E, Silva M, Tassinari W, de Bruycker-Nogueira F, Moraes I, Rodrigues C . Detection of Chikungunya virus in bodily fluids: The INOVACHIK cohort study. PLoS Negl Trop Dis. 2022; 16(3):e0010242. PMC: 8929700. DOI: 10.1371/journal.pntd.0010242. View

12.

Mate S, Kugelman J, Nyenswah T, Ladner J, Wiley M, Cordier-Lassalle T . Molecular Evidence of Sexual Transmission of Ebola Virus. N Engl J Med. 2015; 373(25):2448-54. PMC: 4711355. DOI: 10.1056/NEJMoa1509773. View

13.

van Aalst M, Nelen C, Goorhuis A, Stijnis C, Grobusch M . Long-term sequelae of chikungunya virus disease: A systematic review. Travel Med Infect Dis. 2017; 15:8-22. DOI: 10.1016/j.tmaid.2017.01.004. View

14.

Lanciotti R, Kosoy O, Laven J, Velez J, Lambert A, Johnson A . Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008; 14(8):1232-9. PMC: 2600394. DOI: 10.3201/eid1408.080287. View

15.

Medina F, Torres G, Acevedo J, Fonseca S, Casiano L, De Leon-Rodriguez C . Duration of the Presence of Infectious Zika Virus in Semen and Serum. J Infect Dis. 2018; 219(1):31-40. DOI: 10.1093/infdis/jiy462. View

16.

Mead P, Duggal N, Hook S, Delorey M, Fischer M, McGuire D . Zika Virus Shedding in Semen of Symptomatic Infected Men. N Engl J Med. 2018; 378(15):1377-1385. DOI: 10.1056/NEJMoa1711038. View

17.

Paz-Bailey G, Rosenberg E, Doyle K, Munoz-Jordan J, Santiago G, Klein L . Persistence of Zika Virus in Body Fluids - Final Report. N Engl J Med. 2017; 379(13):1234-1243. PMC: 5831142. DOI: 10.1056/NEJMoa1613108. View

18.

Allen R, Roberts T . The relationship between the immunosuppressive and cytotoxic effects of human seminal plasma. Am J Reprod Immunol Microbiol. 1986; 11(2):59-64. DOI: 10.1111/j.1600-0897.1986.tb00030.x. View

19.

Feldmann H . Virus in Semen and the Risk of Sexual Transmission. N Engl J Med. 2018; 378(15):1440-1441. PMC: 6414222. DOI: 10.1056/NEJMe1803212. View

20.

Dzung A, Cheng P, Stoffel C, Tastanova A, Turko P, Levesque M . Prolonged Unfrozen Storage and Repeated Freeze-Thawing of SARS-CoV-2 Patient Samples Have Minor Effects on SARS-CoV-2 Detectability by RT-PCR. J Mol Diagn. 2021; 23(6):691-697. PMC: 7997259. DOI: 10.1016/j.jmoldx.2021.03.003. View