The Effect of Vitamin D and Its Analogs in Ovarian Cancer

Overview

Journal Nutrients

Date 2022 Sep 23

PMID 36145244

Authors

Karina Piatek

Martin Schepelmann

Eniko Kallay

Affiliations

Soon will be listed here.

Abstract

Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapies with fewer side effects, or adjuvant therapies, which could reduce the necessary doses of chemotherapeutics. Vitamin D is one of the main regulators of serum calcium and phosphorus homeostasis, but it has also anticancer effects. It induces differentiation and apoptosis, reduces proliferation and metastatic potential of cancer cells. However, doses that would be effective against cancer cause hypercalcemia. For this reason, synthetic and less calcemic analogs have been developed and tested in terms of their anticancer effect. The anticancer role of vitamin D is best understood in colorectal, breast, and prostate cancer and much less research has been done in ovarian cancer. In this review, we thus summarize the studies on the role of vitamin D and its analogs in vitro and in vivo in ovarian cancer models.

Citing Articles

Evaluation of the cytotoxic activity of chemically characterized propolis originating from different geographic regions and vitamin D co-supplementation against human ovarian cancer cells.

Ali E, Helmy M, Radwan E, Abdul Aziz K, El-Wahed A, El-Samad L J Ovarian Res. 2024; 17(1):181.

PMID: 39244585 PMC: 11380329. DOI: 10.1186/s13048-024-01500-6.

Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements.

Tavares V, Marques I, de Melo I, Assis J, Pereira D, Medeiros R Int J Mol Sci. 2024; 25(3).

PMID: 38339123 PMC: 10856127. DOI: 10.3390/ijms25031845.

Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies.

Tsuji A, Yoshikawa S, Morikawa S, Ikeda Y, Taniguchi K, Sawamura H Explor Target Antitumor Ther. 2023; 4(3):460-473.

PMID: 37455830 PMC: 10344894. DOI: 10.37349/etat.2023.00145.

A Pleiotropic Nuclear Hormone Labelled Hundred Years Ago Vitamin D.

Carlberg C Nutrients. 2023; 15(1).

PMID: 36615828 PMC: 9823827. DOI: 10.3390/nu15010171.

References

Fu Y, Katsaros D, Biglia N, Wang Z, Pagano I, Tius M . Vitamin D receptor upregulates lncRNA TOPORS-AS1 which inhibits the Wnt/β-catenin pathway and associates with favorable prognosis of ovarian cancer. Sci Rep. 2021; 11(1):7484. PMC: 8021562. DOI: 10.1038/s41598-021-86923-7. View

Rodriguez G, Turbov J, Rosales R, Yoo J, Hunn J, Zappia K . Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention. Gynecol Oncol. 2016; 143(1):159-167. DOI: 10.1016/j.ygyno.2016.04.022. View

Li D, Wang X, Wu J, Quan W, Ma L, Yang F . Tumor-produced versican V1 enhances hCAP18/LL-37 expression in macrophages through activation of TLR2 and vitamin D3 signaling to promote ovarian cancer progression in vitro. PLoS One. 2013; 8(2):e56616. PMC: 3570526. DOI: 10.1371/journal.pone.0056616. View

Guo Y, Jiang F, Yang W, Shi W, Wan J, Li J . Effect of 1α,25(OH)D-Treated M1 and M2 Macrophages on Cell Proliferation and Migration Ability in Ovarian Cancer. Nutr Cancer. 2021; 74(7):2632-2643. DOI: 10.1080/01635581.2021.2014903. View

Berek J, Crum C, Friedlander M . Cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet. 2012; 119 Suppl 2:S118-29. DOI: 10.1016/S0020-7292(12)60025-3. View

Ong J, Cuellar-Partida G, Lu Y, Fasching P, Hein A, Burghaus S . Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. Int J Epidemiol. 2016; 45(5):1619-1630. PMC: 5100621. DOI: 10.1093/ije/dyw207. View

Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B . The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014; 14(5):342-57. DOI: 10.1038/nrc3691. View

Lefkowitz E, Garland C . Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int J Epidemiol. 1994; 23(6):1133-6. DOI: 10.1093/ije/23.6.1133. View

Markowska A, Antoszczak M, Markowska J, Huczynski A . Role of Vitamin E in Selected Malignant Neoplasms in Women. Nutr Cancer. 2021; 74(4):1163-1170. DOI: 10.1080/01635581.2021.1952626. View

10.

Zhang X, Jiang F, Li P, Li C, Ma Q, Nicosia S . Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. Clin Cancer Res. 2005; 11(1):323-8. View

11.

Piatek K, Kutner A, Cacsire Castillo-Tong D, Manhardt T, Kupper N, Nowak U . Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells. Int J Mol Sci. 2022; 23(1). PMC: 8745402. DOI: 10.3390/ijms23010172. View

12.

Xue Y, Wang P, Jiang F, Yu J, Ding H, Zhang Z . A Newly Identified lncBCAS1-4_1 Associated With Vitamin D Signaling and EMT in Ovarian Cancer Cells. Front Oncol. 2021; 11:691500. PMC: 8377733. DOI: 10.3389/fonc.2021.691500. View

13.

Friedrich M, Rafi L, Mitschele T, Tilgen W, Schmidt W, Reichrath J . Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer. Recent Results Cancer Res. 2003; 164:239-46. DOI: 10.1007/978-3-642-55580-0_17. View

14.

Tamura R, de Vasconcellos J, Sarkar D, Libermann T, Fisher P, Zerbini L . GADD45 proteins: central players in tumorigenesis. Curr Mol Med. 2012; 12(5):634-51. PMC: 3797964. DOI: 10.2174/156652412800619978. View

15.

McGlorthan L, Paucarmayta A, Casablanca Y, Maxwell G, Syed V . Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro. Apoptosis. 2021; 26(3-4):184-194. DOI: 10.1007/s10495-021-01657-1. View

16.

Vanhevel J, Verlinden L, Doms S, Wildiers H, Verstuyf A . The role of vitamin D in breast cancer risk and progression. Endocr Relat Cancer. 2021; 29(2):R33-R55. DOI: 10.1530/ERC-21-0182. View

17.

Davicco M, Coxam V, Gaumet N, Lebecque P, Barlet J . EB 1089, a calcitriol analogue, decreases fetal calcium content when injected into pregnant rats. Exp Physiol. 1995; 80(3):449-56. DOI: 10.1113/expphysiol.1995.sp003859. View

18.

Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Kostenberger M, Tmava Berisha A . Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020; 74(11):1498-1513. PMC: 7091696. DOI: 10.1038/s41430-020-0558-y. View

19.

Baurska H, Klopot A, Kielbinski M, Chrobak A, Wijas E, Kutner A . Structure-function analysis of vitamin D(2) analogs as potential inducers of leukemia differentiation and inhibitors of prostate cancer proliferation. J Steroid Biochem Mol Biol. 2011; 126(1-2):46-54. DOI: 10.1016/j.jsbmb.2011.04.006. View

20.

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View