Synthesis of Novel -Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Sep 23

PMID 36144624

Authors

Zengfei Cai

Wenliang Zhang

Zhongjie Yan

Xiaohua Du

Affiliations

Soon will be listed here.

Abstract

To discover novel herbicidal compounds with favorable activity, a range of phenylpyridine-moiety-containing α-trifluorothioanisole derivatives were designed, synthesized, and identified via NMR and HRMS. Preliminary screening of greenhouse-based herbicidal activity revealed that compound 5a exhibited >85% inhibitory activity against broadleaf weeds Amaranthus retroflexus, Abutilon theophrasti, and Eclipta prostrate at 37.5 g a.i./hm2, which was slightly superior to that of fomesafen. The current study suggests that compound 5a could be further optimized as an herbicide candidate to control various broadleaf weeds.

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