» Articles » PMID: 36143230

Choriocapillaris Flow Deficits Quantification in Hydroxychloroquine Retinopathy Using Swept-Source Optical Coherence Tomography Angiography

Overview
Journal J Pers Med
Date 2022 Sep 23
PMID 36143230
Authors
Affiliations
Soon will be listed here.
Abstract

This study aims to quantitatively analyze choriocapillaris (CC) alterations using swept-source optical coherence tomography angiography (SS-OCTA) in eyes presenting with hydroxychloroquine (HCQ) toxic retinopathy and to compare it to patients under HCQ without toxic retinopathy and to healthy controls. For image analysis, CC en-face slabs were extracted from macular 6 × 6 mm SS-OCTA scans and a compensation method followed by the Phansalkar local thresholding was performed. Percentage of flow deficits (FD%) and other related biomarkers were computed for comparison. Fourteen eyes (7 patients) presenting with HCQ toxic retinopathy, sixty-two eyes (31 patients) under HCQ without signs of toxicity, and sixty eyes of 34 healthy controls were included. With regards to FD%, FD average size, and FD number there was a significant difference between the three groups (p < 0.05 with radius 4 and radius 8 pixels). Eyes presenting with HCQ toxicity had significantly higher FD% and average size, and a significantly lower number of FDs, with both radius 4 and 8 pixels. In conclusion, FD quantification demonstrates that CC involvement is present in HCQ toxic retinopathy, therefore giving pathophysiological insights with regards to the CC as being either the primary or secondary target of HCQ toxicity.

Citing Articles

Hydroxychloroquine-induced Retinal Toxicity.

Yusuf I, Charbel Issa P, Ahn S Front Pharmacol. 2023; 14:1196783.

PMID: 37324471 PMC: 10267834. DOI: 10.3389/fphar.2023.1196783.


Review of Retinal Imaging Modalities for Hydroxychloroquine Retinopathy.

Cheong K, Ong C, Chandrasekaran P, Zhao J, Teo K, Mathur R Diagnostics (Basel). 2023; 13(10).

PMID: 37238236 PMC: 10217485. DOI: 10.3390/diagnostics13101752.


Optical coherence tomography angiography features in a case of hydroxychloroquine retinopathy.

Remoli-Sargues L, Monferrer-Adsuara C, Hernandez-Garfella M, Hernandez-Bel L, Castro-Navarro V, Montero-Hernandez J Int J Ophthalmol. 2023; 16(2):325-327.

PMID: 36816201 PMC: 9922623. DOI: 10.18240/ijo.2023.02.24.

References
1.
Borrelli E, Souied E, Freund K, Querques G, Miere A, Gal-Or O . REDUCED CHORIOCAPILLARIS FLOW IN EYES WITH TYPE 3 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION. Retina. 2018; 38(10):1968-1976. DOI: 10.1097/IAE.0000000000002198. View

2.
Rosenbaum J, Costenbader K, Desmarais J, Ginzler E, Fett N, Goodman S . American College of Rheumatology, American Academy of Dermatology, Rheumatologic Dermatology Society, and American Academy of Ophthalmology 2020 Joint Statement on Hydroxychloroquine Use With Respect to Retinal Toxicity. Arthritis Rheumatol. 2021; 73(6):908-911. DOI: 10.1002/art.41683. View

3.
Cook K, Warri A, Soto-Pantoja D, Clarke P, Cruz M, Zwart A . Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer. Clin Cancer Res. 2014; 20(12):3222-32. PMC: 4073207. DOI: 10.1158/1078-0432.CCR-13-3227. View

4.
Allahdina A, Stetson P, Vitale S, Wong W, Chew E, Ferris III F . Optical Coherence Tomography Minimum Intensity as an Objective Measure for the Detection of Hydroxychloroquine Toxicity. Invest Ophthalmol Vis Sci. 2018; 59(5):1953-1963. PMC: 5894928. DOI: 10.1167/iovs.17-22668. View

5.
Choi W, Mohler K, Potsaid B, Lu C, Liu J, Jayaraman V . Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography. PLoS One. 2013; 8(12):e81499. PMC: 3859478. DOI: 10.1371/journal.pone.0081499. View