Does Pyroptosis Play a Role in Inflammasome-Related Disorders?

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Sep 23

PMID 36142364

Authors

Jiajia Zhang

Stefan Wirtz

Affiliations

Soon will be listed here.

Abstract

Inflammasomes are multiprotein complexes orchestrating intracellular recognition of endogenous and exogenous stimuli, cellular homeostasis, and cell death. Upon sensing of certain stimuli, inflammasomes typically activate inflammatory caspases that promote the production and release of the proinflammatory cytokines IL-1β, IL-1α, and IL-18 and induce a type of inflammatory cell death known as "pyroptosis". Pyroptosis is an important form of regulated cell death executed by gasdermin proteins, which is largely different from apoptosis and necrosis. Recently, several signaling pathways driving pyroptotic cell death, including canonical and noncanonical inflammasome activation, as well as caspase-3-dependent pathways, have been reported. While much evidence exists that pyroptosis is involved in the development of several inflammatory diseases, its contribution to inflammasome-related disorders (IRDs) has not been fully clarified. This article reviews molecular mechanisms leading to pyroptosis, and attempts to provide evidence for its possible role in inflammasome-related disorders, including NLR pyrin domain containing 3 (NLRP3) inflammasome disease, NLR containing a caspase recruitment domain 4 (NLRC4) inflammasome disease, and pyrin inflammasome disease. Although the specific mechanism needs further investigations, these studies have uncovered the role of pyroptosis in inflammasome-related disorders and may open new avenues for future therapeutic interventions.

Citing Articles

Extract of Araçá-Boi and Its Major Phenolic Compound, Trans-Cinnamic Acid, Reduce Viability and Inhibit Migration of Human Metastatic Melanoma Cells.

Tecchio Borsoi F, da Silva G, Manica D, Bagatini M, Pastore G, Arruda H Nutrients. 2024; 16(17).

PMID: 39275245 PMC: 11396791. DOI: 10.3390/nu16172929.

MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes.

Bottardi S, Layne T, Ramon A, Quansah N, Wurtele H, Affar E Front Immunol. 2024; 15:1395035.

PMID: 38680493 PMC: 11045911. DOI: 10.3389/fimmu.2024.1395035.

Implications of COVID-19 in Parkinson's disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration.

Simoes J, Braga G, Eichler S, da Silva G, Bagatini M Purinergic Signal. 2024; 20(5):487-507.

PMID: 38460075 PMC: 11377384. DOI: 10.1007/s11302-024-09998-7.

Chemical modulation of gasdermin D activity: Therapeutic implications and consequences.

Zhou B, Abbott D Semin Immunol. 2023; 70:101845.

PMID: 37806032 PMC: 10841450. DOI: 10.1016/j.smim.2023.101845.

Differences and Associations of NLRP3 Inflammasome Levels with Interleukins 1α, 1β, 33 and 37 in Adults with Prediabetes and Type 2 Diabetes Mellitus.

Alfadul H, Sabico S, Ansari M, Alnaami A, Amer O, Hussain S Biomedicines. 2023; 11(5).

PMID: 37238986 PMC: 10216290. DOI: 10.3390/biomedicines11051315.

References

Taabazuing C, Okondo M, Bachovchin D . Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages. Cell Chem Biol. 2017; 24(4):507-514.e4. PMC: 5467448. DOI: 10.1016/j.chembiol.2017.03.009. View

Saitoh T, Fujita N, Jang M, Uematsu S, Yang B, Satoh T . Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008; 456(7219):264-8. DOI: 10.1038/nature07383. View

Wang X, Li H, Li W, Xie J, Wang F, Peng X . The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy. Cell Biol Toxicol. 2020; 36(5):437-457. DOI: 10.1007/s10565-020-09514-8. View

Chen K, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady C . Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly. EMBO J. 2019; 38(10). PMC: 6517827. DOI: 10.15252/embj.2019101638. View

Magna M, Pisetsky D . The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?. Scand J Immunol. 2015; 82(3):218-24. DOI: 10.1111/sji.12335. View

Yuan X, Gajan A, Chu Q, Xiong H, Wu K, Wu G . Developing TRAIL/TRAIL death receptor-based cancer therapies. Cancer Metastasis Rev. 2018; 37(4):733-748. PMC: 6138568. DOI: 10.1007/s10555-018-9728-y. View

Rathinam V, Zhao Y, Shao F . Innate immunity to intracellular LPS. Nat Immunol. 2019; 20(5):527-533. PMC: 7668400. DOI: 10.1038/s41590-019-0368-3. View

Lee J, Kim S, Lewis E, Azam T, Reznikov L, Dinarello C . Differences in signaling pathways by IL-1beta and IL-18. Proc Natl Acad Sci U S A. 2004; 101(23):8815-20. PMC: 423278. DOI: 10.1073/pnas.0402800101. View

Peng X, Yang T, Liu G, Liu H, Peng Y, He L . Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome. Int Immunopharmacol. 2018; 65:448-457. DOI: 10.1016/j.intimp.2018.10.025. View

10.

Shao S, Chen C, Shi G, Zhou Y, Wei Y, Fan N . Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis. Pharmacol Ther. 2021; 227:107880. DOI: 10.1016/j.pharmthera.2021.107880. View

11.

Kahlenberg J, Carmona-Rivera C, Smith C, Kaplan M . Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. J Immunol. 2012; 190(3):1217-26. PMC: 3552129. DOI: 10.4049/jimmunol.1202388. View

12.

Li D, Shi G, Wang J, Zhang D, Pan Y, Dou H . Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells. Arthritis Res Ther. 2019; 21(1):105. PMC: 6482536. DOI: 10.1186/s13075-019-1876-0. View

13.

Chen H, Deng Y, Gan X, Li Y, Huang W, Lu L . NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma. Mol Neurodegener. 2020; 15(1):26. PMC: 7161290. DOI: 10.1186/s13024-020-00372-w. View

14.

Kaczmarek-Rys M, Hryhorowicz S, Lis E, Banasiewicz T, Paszkowski J, Borejsza-Wysocki M . Crohn's Disease Susceptibility and Onset Are Strongly Related to Three Gene Haplotypes. J Clin Med. 2021; 10(17). PMC: 8432186. DOI: 10.3390/jcm10173777. View

15.

Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A . Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients. EMBO Mol Med. 2019; 11(11):e10547. PMC: 6835204. DOI: 10.15252/emmm.201910547. View

16.

Man S, Karki R, Kanneganti T . Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev. 2017; 277(1):61-75. PMC: 5416822. DOI: 10.1111/imr.12534. View

17.

Grootjans S, Vanden Berghe T, Vandenabeele P . Initiation and execution mechanisms of necroptosis: an overview. Cell Death Differ. 2017; 24(7):1184-1195. PMC: 5520172. DOI: 10.1038/cdd.2017.65. View

18.

Wang Y, Gao W, Shi X, Ding J, Liu W, He H . Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017; 547(7661):99-103. DOI: 10.1038/nature22393. View

19.

Franco-Trepat E, Alonso-Perez A, Guillan-Fresco M, Jorge-Mora A, Crespo-Golmar A, Lopez-Fagundez M . Amitriptyline blocks innate immune responses mediated by toll-like receptor 4 and IL-1 receptor: Preclinical and clinical evidence in osteoarthritis and gout. Br J Pharmacol. 2021; 179(2):270-286. PMC: 9300168. DOI: 10.1111/bph.15707. View

20.

Canna S, de Jesus A, Gouni S, Brooks S, Marrero B, Liu Y . An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet. 2014; 46(10):1140-6. PMC: 4177369. DOI: 10.1038/ng.3089. View