Moderate and Severe Dental Fluorosis in the Rural Population of Anantapur, India: Change in Their Biological Susceptibility?

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Sep 23

PMID 36141562

Authors

Trina Mylena Garcia-Escobar

Ivan Valdivia-Gandur

Wilson Astudillo-Rozas

Oscar Aceituno-Antezana

Balasubbaiah Yamadala

Vicente Lozano de Luaces

Eduardo Chimenos-Kustner

Maria Cristina Manzanares-Cespedes

Affiliations

Soon will be listed here.

Abstract

Dental fluorosis affects the quality of life. A cross-sectional, observational study was conducted in a community affected by endemic fluorosis for several generations with a conserved biological and social environment. The study included patients from the rural population of Anantapur, India. The Dean index (DI) and the Thylstrup and Fejerskov Index (TFI) were used for fluorosis classification. Additionally, water samples were collected for fluoride analysis, taken from the patients' living areas. The statistical association between the variables was analyzed. In total, 785 patients between 10 and 60 years old were included in the study (58.7% women and 41.3% men). Fluorosis signs were found in 94.6% of patients examined using the DI and 94.4% using the TFI. Moderate-severe dental fluorosis was observed in 62.8% by DI and 73.1% by TFI consuming untreated water with up to 2.9 ppm of fluoride. Furthermore, moderate-severe dental fluorosis was observed in 33.2% by DI and 39.9% by TFI consuming water with ≤1.5 ppm of fluoride. The high prevalence of moderate-severe dental fluorosis in patients consuming water with a low fluoride concentration suggests that other factors are involved. Biological susceptibility change could play an essential role in the severity of dental fluorosis in populations exposed for several generations, affecting its actual and future quality of life.

References

Sebastian S, Soman R, Sunitha S . Prevalence of dental fluorosis among primary school children in association with different water fluoride levels in Mysore district, Karnataka. Indian J Dent Res. 2016; 27(2):151-4. DOI: 10.4103/0970-9290.183126. View

Kuchler E, Tannure P, Oliveira D, Charone S, Nelson-Filho P, da Silva R . Polymorphisms in genes involved in enamel development are associated with dental fluorosis. Arch Oral Biol. 2017; 76:66-69. DOI: 10.1016/j.archoralbio.2017.01.009. View

Rahila C, Aswath Narayanan M, Ramesh Kumar S, Selvamary A, Sujatha A, John Kirubaharan J . Association of COL1A2 (PvuII) gene polymorphism with risk and severity of dental fluorosis - A case control study. Saudi Dent J. 2019; 31(4):463-468. PMC: 6823789. DOI: 10.1016/j.sdentj.2019.05.004. View

Everett E, McHenry M, Reynolds N, Eggertsson H, Sullivan J, Kantmann C . Dental fluorosis: variability among different inbred mouse strains. J Dent Res. 2002; 81(11):794-8. DOI: 10.1177/0810794. View

Fareed M, Afzal M . Genetics of consanguinity and inbreeding in health and disease. Ann Hum Biol. 2016; 44(2):99-107. DOI: 10.1080/03014460.2016.1265148. View

Thylstrup A, Fejerskov O . Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changes. Community Dent Oral Epidemiol. 1978; 6(6):315-28. DOI: 10.1111/j.1600-0528.1978.tb01173.x. View

Miousse I, Currie R, Datta K, Ellinger-Ziegelbauer H, French J, Harrill A . Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute. Toxicology. 2015; 335:11-9. DOI: 10.1016/j.tox.2015.06.009. View

Jagtap S, Yenkie M, Labhsetwar N, Rayalu S . Fluoride in drinking water and defluoridation of water. Chem Rev. 2012; 112(4):2454-66. DOI: 10.1021/cr2002855. View

Akpata E, Fakiha Z, Khan N . Dental fluorosis in 12-15-year-old rural children exposed to fluorides from well drinking water in the Hail region of Saudi Arabia. Community Dent Oral Epidemiol. 1997; 25(4):324-7. DOI: 10.1111/j.1600-0528.1997.tb00947.x. View

10.

Manji F, Baelum V, Fejerskov O . Dental fluorosis in an area of Kenya with 2 ppm fluoride in the drinking water. J Dent Res. 1986; 65(5):659-62. DOI: 10.1177/00220345860650050501. View

11.

Jarquin-Yneza L, Alegria-Torres J, Castillo C, Mejia-Saavedra J . Dental fluorosis and a polymorphism in the COL1A2 gene in Mexican children. Arch Oral Biol. 2018; 96:21-25. DOI: 10.1016/j.archoralbio.2018.08.010. View

12.

Kumar M, Puri A . A review of permissible limits of drinking water. Indian J Occup Environ Med. 2012; 16(1):40-4. PMC: 3482709. DOI: 10.4103/0019-5278.99696. View

13.

Pramanik S, Saha D . The genetic influence in fluorosis. Environ Toxicol Pharmacol. 2017; 56:157-162. DOI: 10.1016/j.etap.2017.09.008. View

14.

Aldosari A, Akpata E, Khan N . Associations among dental caries experience, fluorosis, and fluoride exposure from drinking water sources in Saudi Arabia. J Public Health Dent. 2010; 70(3):220-6. DOI: 10.1111/j.1752-7325.2010.00169.x. View

15.

Shanthi M, Reddy B, Venkataramana V, Gowrisankar S, Reddy B, Chennupati S . Relationship Between Drinking Water Fluoride Levels, Dental Fluorosis, Dental Caries and Associated Risk Factors in 9-12 Years Old School Children of Nelakondapally Mandal of Khammam District, Andhra Pradesh, India: A Cross-sectional Survey. J Int Oral Health. 2014; 6(3):106-10. PMC: 4109249. View

16.

Williams J, ZWEMER J . Community water fluoride levels, preschool dietary patterns, and the occurrence of fluoride enamel opacities. J Public Health Dent. 1990; 50(4):276-81. DOI: 10.1111/j.1752-7325.1990.tb02135.x. View

17.

Suzuki M, Ikeda A, Bartlett J . Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation. Arch Toxicol. 2017; 92(3):1283-1293. PMC: 6667832. DOI: 10.1007/s00204-017-2135-2. View

18.

Shekar C, Cheluvaiah M, Namile D . Prevalence of dental caries and dental fluorosis among 12 and 15 years old school children in relation to fluoride concentration in drinking water in an endemic fluoride belt of Andhra Pradesh. Indian J Public Health. 2012; 56(2):122-8. DOI: 10.4103/0019-557X.99902. View

19.

Saha D, Goswami R, Majumdar K, Sikdar N, Pramanik S . Evaluating the Association Between Dental Fluorosis and Polymorphisms in Bone Development and Mineralization Genes Among Population from a Fluoride Endemic Region of Eastern India. Biol Trace Elem Res. 2020; 199(1):1-8. DOI: 10.1007/s12011-020-02116-9. View

20.

Daiwile A, Tarale P, Sivanesan S, Naoghare P, Bafana A, Parmar D . Role of fluoride induced epigenetic alterations in the development of skeletal fluorosis. Ecotoxicol Environ Saf. 2018; 169:410-417. DOI: 10.1016/j.ecoenv.2018.11.035. View