Fluorescence-Guided Surgery and Novel Innovative Technologies for Improved Visualization in Pediatric Urology

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Sep 23

PMID 36141458

Authors

Irene Paraboschi

Guglielmo Mantica

Dario Guido Minoli

Erika Adalgisa De Marco

Michele Gnech

Carolina Bebi

Gianantonio Manzoni

Alfredo Berrettini

Affiliations

Soon will be listed here.

Abstract

Fluorescence-guided surgery (FGS), three-dimensional (3D) imaging technologies, and other innovative devices are rapidly revolutionizing the field of urology, providing surgeons with powerful tools for a more complete understanding of patient-specific anatomy. Today, several new intraoperative imaging technologies and cutting-edge devices are available in adult urology to assist surgeons in delivering personalized interventions. Their applications are also gradually growing in general pediatric surgery, where the detailed visualization of normal and pathological structures has the potential to significantly minimize perioperative complications and improve surgical outcomes. In the field of pediatric urology, FGS, 3D reconstructions and printing technologies, augmented reality (AR) devices, contrast-enhanced ultrasound (CEUS), and intraoperative magnetic resonance imaging (iMRI) have been increasingly adopted for a more realistic understanding of the normal and abnormal anatomy, providing a valuable insight to deliver customized treatments in real time. This narrative review aims to illustrate the main applications of these new technologies and imaging devices in the clinical setting of pediatric urology by selecting, with a strict methodology, the most promising articles published in the international scientific literature on this topic. The purpose is to favor early adoption and stimulate more research on this topic for the benefit of children.

Citing Articles

Minimally Invasive Surgery for Hirschsprung Disease: Current Practices and Future Directions.

Almadhoun M, Morcos R, Alsadoun L, Bokhari S, Ahmed Z, Khilji F Cureus. 2024; 16(8):e66444.

PMID: 39246990 PMC: 11380471. DOI: 10.7759/cureus.66444.

Preoperative three-dimensional modelling and virtual reality planning aids nephron sparing surgery in a child with bilateral Wilms tumour.

Banerjee A, Babu R, Jayaraman D, Chilukuri S BMJ Case Rep. 2024; 17(4).

PMID: 38642931 PMC: 11033631. DOI: 10.1136/bcr-2024-260600.

Surgery in Bilateral Wilms Tumor-A Single-Center Experience.

Souza F, Fanelli M, Duarte A, Alves M, Lederman H, Cypriano M Children (Basel). 2023; 10(11).

PMID: 38002881 PMC: 10670692. DOI: 10.3390/children10111790.

Evaluation of testicular blood flow during testicular torsion surgery in children using the indocyanine green-guided near-infrared fluorescence imaging technique.

Liu X, Xu Y, Li L, Bai D Front Pediatr. 2023; 11:1272659.

PMID: 37964816 PMC: 10642505. DOI: 10.3389/fped.2023.1272659.

Indocyanine Green (ICG)-Guided One-Stage Delayed Bladder Closure and Radical Soft-Tissue Mobilization (Kelly Procedure) For Bladder Exstrophy Repair: The First Experience.

Paraboschi I, Gnech M, Minoli D, De Marco E, Parente G, Mantica G Res Rep Urol. 2023; 15:375-380.

PMID: 37581016 PMC: 10423616. DOI: 10.2147/RRU.S423521.

References

cizmarevic U, Hanzic N, Zerdin M . The Use of Contrast-enhanced Ultrasound in Pediatrics: A Case Series. Cureus. 2020; 11(11):e6215. PMC: 6929255. DOI: 10.7759/cureus.6215. View

Tekes A, Ertan G, Solaiyappan M, Stec A, Sponseller P, Huisman T . 2D and 3D MRI features of classic bladder exstrophy. Clin Radiol. 2014; 69(5):e223-9. DOI: 10.1016/j.crad.2013.12.019. View

Jarboe M, Teitelbaum D, Dillman J . Combined 3D rotational fluoroscopic-MRI cloacagram procedure defines luminal and extraluminal pelvic anatomy prior to surgical reconstruction of cloacal and other complex pelvic malformations. Pediatr Surg Int. 2012; 28(8):757-63. DOI: 10.1007/s00383-012-3122-6. View

van den Berg N, van Leeuwen F, van der Poel H . Fluorescence guidance in urologic surgery. Curr Opin Urol. 2012; 22(2):109-20. DOI: 10.1097/MOU.0b013e3283501869. View

Chaussy Y, Vieille L, Lacroix E, Lenoir M, Marie F, Corbat L . 3D reconstruction of Wilms' tumor and kidneys in children: Variability, usefulness and constraints. J Pediatr Urol. 2020; 16(6):830.e1-830.e8. DOI: 10.1016/j.jpurol.2020.08.023. View

Nguyen Q, Tsien R . Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nat Rev Cancer. 2013; 13(9):653-62. PMC: 4427343. DOI: 10.1038/nrc3566. View

Esposito C, Turra F, Del Conte F, Izzo S, Gargiulo F, Farina A . Indocyanine Green Fluorescence Lymphography: A New Technique to Perform Lymphatic Sparing Laparoscopic Palomo Varicocelectomy in Children. J Laparoendosc Adv Surg Tech A. 2019; 29(4):564-567. DOI: 10.1089/lap.2018.0624. View

Souzaki R, Kawakubo N, Matsuura T, Yoshimaru K, Koga Y, Takemoto J . Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients. Pediatr Surg Int. 2019; 35(5):551-557. DOI: 10.1007/s00383-019-04458-5. View

Privitera L, Paraboschi I, Cross K, Giuliani S . Above and Beyond Robotic Surgery and 3D Modelling in Paediatric Cancer Surgery. Front Pediatr. 2022; 9:777840. PMC: 8721224. DOI: 10.3389/fped.2021.777840. View

10.

Abdelhafeez A, Murphy A, Brennan R, Santiago T, Lu Z, Krasin M . Indocyanine green-guided nephron-sparing surgery for pediatric renal tumors. J Pediatr Surg. 2021; 57(9):174-178. DOI: 10.1016/j.jpedsurg.2021.08.006. View

11.

Yousefifard M, Toloui A, Alavi S, Madani Neishaboori A, Ahmadzadeh K, Ghelichkhani P . Contrast-enhanced voiding urosonography, a possible candidate for the diagnosis of vesicoureteral reflux in children and adolescents; a systematic review and meta-analysis. J Pediatr Urol. 2021; 18(1):61-74. DOI: 10.1016/j.jpurol.2021.10.023. View

12.

Rassweiler J, Muller M, Fangerau M, Klein J, Goezen A, Pereira P . iPad-assisted percutaneous access to the kidney using marker-based navigation: initial clinical experience. Eur Urol. 2012; 61(3):628-31. DOI: 10.1016/j.eururo.2011.12.024. View

13.

Herz D, DaJusta D, Ching C, McLeod D . Segmental arterial mapping during pediatric robot-assisted laparoscopic heminephrectomy: A descriptive series. J Pediatr Urol. 2016; 12(4):266.e1-6. DOI: 10.1016/j.jpurol.2016.04.021. View

14.

Amparore D, Pecoraro A, Checcucci E, De Cillis S, Piramide F, Volpi G . 3D imaging technologies in minimally invasive kidney and prostate cancer surgery: which is the urologists' perception?. Minerva Urol Nephrol. 2021; 74(2):178-185. DOI: 10.23736/S2724-6051.21.04131-X. View

15.

Wellens L, Meulstee J, van de Ven C, Terwisscha van Scheltinga C, Littooij A, van den Heuvel-Eibrink M . Comparison of 3-Dimensional and Augmented Reality Kidney Models With Conventional Imaging Data in the Preoperative Assessment of Children With Wilms Tumors. JAMA Netw Open. 2019; 2(4):e192633. PMC: 6481457. DOI: 10.1001/jamanetworkopen.2019.2633. View

16.

Bertolo R, Hung A, Porpiglia F, Bove P, Schleicher M, Dasgupta P . Systematic review of augmented reality in urological interventions: the evidences of an impact on surgical outcomes are yet to come. World J Urol. 2019; 38(9):2167-2176. DOI: 10.1007/s00345-019-02711-z. View

17.

Ebert A, Falkert A, Germer U, Rosch W . Biometry of the pubovisceral muscle and levator hiatus assessed by three-dimensional ultrasound in females with bladder exstrophy-epispadias complex after functional reconstruction. Ultrasound Obstet Gynecol. 2009; 34(1):98-103. DOI: 10.1002/uog.6429. View

18.

Duran C, Beltran V, Gonzalez A, Gomez C, Del Riego J . Contrast-enhanced Voiding Urosonography for Vesicoureteral Reflux Diagnosis in Children. Radiographics. 2017; 37(6):1854-1869. DOI: 10.1148/rg.2017170024. View

19.

Nagaya T, Nakamura Y, Choyke P, Kobayashi H . Fluorescence-Guided Surgery. Front Oncol. 2018; 7:314. PMC: 5743791. DOI: 10.3389/fonc.2017.00314. View

20.

Esposito C, Del Conte F, Cerulo M, Gargiulo F, Izzo S, Esposito G . Clinical application and technical standardization of indocyanine green (ICG) fluorescence imaging in pediatric minimally invasive surgery. Pediatr Surg Int. 2019; 35(10):1043-1050. DOI: 10.1007/s00383-019-04519-9. View