C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2022 Sep 23

PMID 36140804

Authors

Sonali Bhakta

Toshifumi Tsukahara

Affiliations

Soon will be listed here.

Abstract

The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which gene editing (editing of mutated genes) is a promising therapeutic technique. In C-to-Uridine (U) RNA editing, it converts the base C-to-U in RNA molecules and leads to nonsynonymous changes when occurring in coding regions; however, for G-to-A mutations, A-to-I editing occurs. Editing of C-to-U is not as physiologically common as that of A-to-I editing. Although hundreds to thousands of coding sites have been found to be C-to-U edited or editable in humans, the biological significance of this phenomenon remains elusive. In this review, we have tried to provide detailed information on physiological and artificial approaches for C-to-U RNA editing.

Citing Articles

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