» Articles » PMID: 36140046

Photodynamic Therapy by Mean of 5-Aminolevulinic Acid for the Management of Periodontitis and Peri-Implantitis: A Retrospective Analysis of 20 Patients

Overview
Specialty Pharmacology
Date 2022 Sep 23
PMID 36140046
Authors
Affiliations
Soon will be listed here.
Abstract

Periodontitis and peri-implantitis are common in the population worldwide. Periodontal diseases affect approximately 50% of adults, while mucositis affects 80% of patients with implants, turning into peri-implantitis at a rate varying from 28 to 58%. If standardized treatments for all degrees and variety of periodontal diseases are known and codified, a consensus on the treatment of peri-implantitis still has to be found. Photodynamic therapy (PDT) has been used successfully in the medical field and was recently introduced as supportive therapy in dentistry. This paper reviews the results on 20 patients, 10 affected by periodontal disease (grades II to III) and 10 by peri-implantitis. Application of 5% 5-aminolevulinic acid gel (ALAD), as a support of causal therapy, in periodontal pockets and areas of peri-implantitis favored the maintenance of severely compromised teeth and significantly improved compromised implant conditions. Between baseline and 6 months, all teeth and implants remained functional. All patients confirmed that the scaling and root planning (SRP)+ALAD-PDT was not painful, and all perceived a benefit after the treatment at all timing points. For periodontal patients, a significant decrease in PPD after 3 (p < 0.001) and 6 months after SRP+ALAD-PDT respect baseline values were observed. For the implant patients, the SRP+ALAD-PDT was correlated to a decrease in PPD and BOP, and a slight increase in the number of exposed threads. However, the results were statistically significant only for PPD (p < 0.001).

Citing Articles

Revisiting Socransky's Complexes: A Review Suggesting Updated New Bacterial Clusters (GF-MoR Complexes) for Periodontal and Peri-Implant Diseases and Conditions.

Fernandes G, Mosley G, Ross W, Dagher A, Martins B, Fernandes J Microorganisms. 2024; 12(11).

PMID: 39597602 PMC: 11596145. DOI: 10.3390/microorganisms12112214.


Red Light and 5% Aminolaevulinic Acid (5%) Inhibit Proliferation and Migration of Dysplastic Oral Keratinocytes via ROS Production: An In Vitro Study.

Pierfelice T, Lazarevic M, Mitic D, Nikolic N, Radunovic M, Iezzi G Gels. 2023; 9(8).

PMID: 37623059 PMC: 10453269. DOI: 10.3390/gels9080604.


Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity of Cells Cultured on Porcine Acellular Dermal Matrix Membranes Used in Periodontology.

Petrini M, DAmico E, Pierfelice T, Aceto G, Karaban M, Felice P Gels. 2023; 9(7).

PMID: 37504463 PMC: 10379034. DOI: 10.3390/gels9070584.


Functionalization of a Cortical Membrane with a Photodynamic Protocol.

Pierfelice T, DAmico E, DErcole S, Lepore S, Piattelli A, Barone A J Funct Biomater. 2023; 14(3).

PMID: 36976057 PMC: 10057199. DOI: 10.3390/jfb14030133.


The Involvement of Photobiology in Contemporary Dentistry-A Narrative Review.

Luchian I, Budala D, Baciu E, Ursu R, Diaconu-Popa D, Butnaru O Int J Mol Sci. 2023; 24(4).

PMID: 36835395 PMC: 9961259. DOI: 10.3390/ijms24043985.


References
1.
Lang N, Bartold P . Periodontal health. J Periodontol. 2018; 89 Suppl 1:S9-S16. DOI: 10.1002/JPER.16-0517. View

2.
Cieplik F, Deng D, Crielaard W, Buchalla W, Hellwig E, Al-Ahmad A . Antimicrobial photodynamic therapy - what we know and what we don't. Crit Rev Microbiol. 2018; 44(5):571-589. DOI: 10.1080/1040841X.2018.1467876. View

3.
Amos-Tautua B, Songca S, Oluwafemi O . Application of Porphyrins in Antibacterial Photodynamic Therapy. Molecules. 2019; 24(13). PMC: 6650910. DOI: 10.3390/molecules24132456. View

4.
Oliveira R, Schwartz-Filho H, Novaes Jr A, Taba Jr M . Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study. J Periodontol. 2007; 78(6):965-73. DOI: 10.1902/jop.2007.060494. View

5.
Chondros P, Nikolidakis D, Christodoulides N, Rossler R, Gutknecht N, Sculean A . Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. Lasers Med Sci. 2008; 24(5):681-8. DOI: 10.1007/s10103-008-0565-z. View