Investigation of Microbial Translocation, and Gene Polymorphisms, and Recurrence Risk in Stage III Colorectal Cancer Patients

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Sep 23

PMID 36139567

Authors

Ippokratis Messaritakis

Asimina Koulouridi

Eleni Boukla

Maria Sfakianaki

Konstantinos Vogiatzoglou

Michaela Karagianni

Nikolaos Gouvas

John Tsiaoussis

Evangelos Xynos

Elias Athanasakis

Dimitrios Mavroudis

Maria Tzardi

John Souglakos

Affiliations

Soon will be listed here.

Abstract

Gut microbial dysbiosis and microbial passage into the peripheral blood leads to colorectal cancer (CRC) and disease progression. Toll-like () and vitamin D () receptors play important role in the immune modulation and polymorphisms that may increase CRC risk and death rates. The aim of the current study was to demonstrate the prognostic value of microbial DNA fragments in the blood of stage III CRC patients and correlate such microbial detection to polymorphisms. Peripheral blood was collected from 132 patients for the detection of microbial DNA fragments, and / gene polymorphisms. In the detection of various microbial DNA fragments, and polymorphisms was significantly higher compared to healthy group. Homozygous individuals of either or polymorphisms had significantly higher detection rates of microbial DNA fragments. Mutational and MSI status were significantly correlated with and polymorphisms. Significantly shorter disease-free survival was associated with patients with mutated tumors and I polymorphisms, whereas shorter overall survival was associated with the detection of . The detection of B. fragilis, as demonstrated by the multivariate analysis, is an independent poor prognostic factor for shorter disease-free survival. genetic variants were significantly correlated with the detection of microbial fragments in the blood, and this in turn is significantly associated with tumorigenesis and disease progression.

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