Neurogenesis During Brittle Star Arm Regeneration Is Characterised by a Conserved Set of Key Developmental Genes

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2022 Sep 23

PMID 36138839

Authors

Anna Czarkwiani

Jack Taylor

Paola Oliveri

Affiliations

Soon will be listed here.

Abstract

Neural regeneration is very limited in humans but extremely efficient in echinoderms. The brittle star can regenerate both components of its central nervous system as well as the peripheral system, and understanding the molecular mechanisms underlying this ability is key for evolutionary comparisons not only within the echinoderm group, but also wider within deuterostomes. Here we characterise the neural regeneration of this brittle star using a combination of immunohistochemistry, in situ hybridization and Nanostring nCounter to determine the spatial and temporal expression of evolutionary conserved neural genes. We find that key genes crucial for the embryonic development of the nervous system in sea urchins and other animals are also expressed in the regenerating nervous system of the adult brittle star in a hierarchic and spatio-temporally restricted manner.

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