Effects of Exposure Duration and Exposure Levels of Ambient Air Pollutants on the Risk of Polycystic Ovarian Syndrome: A 2015-2019 Korean Population-Based Cohort Study

Overview

Journal Toxics

Date 2022 Sep 22

PMID 36136507

Authors

Ju-Hee Kim

Se-Hwa Hong

Na-Lae Moon

Dae-Ryong Kang

Affiliations

Soon will be listed here.

Abstract

Exposure to ambient air pollution is associated with an increased risk of menstrual disorders and infertility. This study examined the relationships between the levels and duration of air pollution exposure and the risk of polycystic ovarian syndrome (PCOS) using Korean population-based cohort data (2015-2019). Real-time data on PM, PM, O, CO, SO, and NO were provided by the Korean Ministry of Environment. The average monthly air pollutant concentration from 1 January 2014 to 31 December 2018 was analyzed. To assess individual-level exposure to air pollutants, a spatial prediction model and an area-averaging approach were used. In total, 237,582 PCOS cases were analyzed. The annual age-adjusted PCOS incidence was 6.70, 8.28, 9.73, 11.58, and 11.97% from 2015-2019, respectively. The PCOS risk increased 1.29-1.32, 1.43-1.52, and 1.32-fold following exposure to the 2-year and 3-year average levels of PM, O, and NO, respectively, compared to their 1-year average levels. The PCOS risk increased 1.75-fold (95% confidence interval: 1.66-1.85) in the fourth-quartile for the NO level. Increased SO and CO levels in the second- and third-quartiles were also associated with an increased PCOS risk. Exposure to air pollutants thus increased the risk for PCOS in the Korean population.

Citing Articles

Fine particulate matter and ovarian health: A review of emerging risks.

Tao Q, Zhao Z, Yang R, Li Q, Qiao J Heliyon. 2024; 10(22):e40503.

PMID: 39650185 PMC: 11625118. DOI: 10.1016/j.heliyon.2024.e40503.

Environmental health and women's health nursing.

Kim J Womens Health Nurs. 2024; 30(3):175-177.

PMID: 39385543 PMC: 11467247. DOI: 10.4069/whn.2024.08.20.

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