Concurrent Assessment of Phthalates/HEXAMOLL DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies

Overview

Journal Toxics

Date 2022 Sep 22

PMID 36136503

Authors

Valentina Rosolen

Elisa Giordani

Marika Mariuz

Maria Parpinel

Luca Ronfani

Liza Vecchi Brumatti

Maura Bin

Gemma Calamandrei

Vicente Mustieles

Liese Gilles

Eva Govarts

Kirsten Baken

Laura Rodriguez Martin

Greet Schoeters

Ovnair Sepai

Eva Sovcikova

Lucia Fabelova

Miroslava Sidlovska

Branislav Kolena

Tina Kold Jensen

Hanne Frederiksen

Marike Kolossa-Gehring

Rosa Lange

Petra Apel

Argelia Castano

Marta Esteban Lopez

Griet Jacobs

Stefan Voorspoels

Helena Jurdakova

Renata Gorova

Fabio Barbone

Affiliations

Soon will be listed here.

Abstract

Information about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL DINCH) on children's neurodevelopment is limited. The aim of the present research is to evaluate the association between phthalate/HEXAMOLL DINCH exposure and child neurodevelopment in three European cohorts involved in HBM4EU Aligned Studies. Participating subjects were school-aged children belonging to the Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, and PCB cohort, Slovakia. In each cohort, children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score (FSIQ) of the Wechsler Intelligence Scale of Children test using three different editions. The children's urine samples, collected for one point in time concurrently with the neurodevelopmental evaluation, were analyzed for several phthalates/HEXAMOLL DINCH biomarkers. The relation between phthalates/HEXAMOLL DINCH and FSIQ was explored by applying separate multiple linear regressions in each cohort. The means and standard deviations of FSIQ were 109 ± 11 (NAC-II), 98 ± 12 (OCC), and 81 ± 15 (PCB cohort). In NAC-II, direct associations between FSIQ and DEHP's biomarkers were found: 5OH-MEHP+5oxo-MEHP (β = 2.56; 95% CI 0.58-4.55; N = 270), 5OH-MEHP+5cx-MEPP (β = 2.48; 95% CI 0.47-4.49; N = 270) and 5OH-MEHP (β = 2.58; 95% CI 0.65-4.51; N = 270). On the contrary, in the OCC the relation between DEHP's biomarkers and FSIQ tended to be inverse but imprecise (-value ≥ 0.10). No associations were found in the PCB cohort. FSIQ was not associated with HEXAMOLL DINCH in any cohort. In conclusion, these results do not provide evidence of an association between concurrent phthalate/DINCHHEXAMOLLR DINCH exposure and IQ in children.

Citing Articles

Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies.

Salamanca-Fernandez E, Espin-Moreno L, Olivas-Martinez A, Perez-Cantero A, Martin-Rodriguez J, Poyatos R Toxics. 2024; 12(9).

PMID: 39330570 PMC: 11436069. DOI: 10.3390/toxics12090642.

Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements.

Morales-Grahl E, Hilz E, Gore A Int J Mol Sci. 2024; 25(13).

PMID: 38999997 PMC: 11241431. DOI: 10.3390/ijms25136887.

Cognitive Performance and Exposure to Organophosphate Flame Retardants in Children: Evidence from a Cross-Sectional Analysis of Two European Mother-Child Cohorts.

Rosolen V, Giordani E, Mariuz M, Parpinel M, Mustieles V, Gilles L Toxics. 2023; 11(11).

PMID: 37999530 PMC: 10675051. DOI: 10.3390/toxics11110878.

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