Fosfomycin Protects Against Tubulotoxicity Induced by Cis-diaminedichloroplatin and Cyclosporin A in the Rat

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1987 Jun 1

PMID 3613466

Citations 5

Authors

K Sack

E Schulz

R Marre

B Kreft

Affiliations

Soon will be listed here.

Abstract

The nephroprotective effect of fosfomycin against tubulotoxicity induced by cis-diaminedichloroplatin (DDP) and cyclosporin A (Cs) was studied in the rat. The parameter of nephrotoxicity was urinary tubular cell excretion. The experiments revealed that fosfomycin, given either concomitantly or in advance was able to reduce the nephrotoxic effect of DDP and Cs significantly. We conclude from these studies that fosfomycin is a broad-spectrum nephroprotective agent.

Citing Articles

Effect of Fosfomycin on Cyclosporine Nephrotoxicity.

Ortega-Trejo J, Perez-Villalva R, Arreola-Guerra J, Ramirez V, Sifuentes-Osornio J, Bobadilla N Antibiotics (Basel). 2020; 9(10).

PMID: 33096599 PMC: 7589799. DOI: 10.3390/antibiotics9100720.

Fosfomycin: Uses and potentialities in veterinary medicine.

Perez D, Tapia M, Soraci A Open Vet J. 2015; 4(1):26-43.

PMID: 26623336 PMC: 4629597.

Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice.

Matsumoto T, Tateda K, Miyazaki S, Furuya N, Ohno A, Ishii Y Antimicrob Agents Chemother. 1997; 41(2):308-13.

PMID: 9021184 PMC: 163706. DOI: 10.1128/AAC.41.2.308.

Effects of fosfomycin, mesna, and sodium thiosulfate on the toxicity and antitumor activity of cisplatin.

Wagner T, Kreft B, Bohlmann G, Schwieder G J Cancer Res Clin Oncol. 1988; 114(5):497-501.

PMID: 3141427 DOI: 10.1007/BF00391499.

The microbiological efficacy of the combination of fosfomycin and vancomycin against clinically relevant staphylococci.

Gatermann S, Schulz E, Marre R Infection. 1989; 17(1):35-7.

PMID: 2921087 DOI: 10.1007/BF01643498.

References

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