L-Lysine Ameliorates Diabetic Nephropathy in Rats with Streptozotocin-Induced Diabetes Mellitus

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2022 Sep 22

PMID 36132073

Authors

Faezeh Jozi

Nejat Kheiripour

Maryam Akhavan Taheri

Abolfazl Ardjmand

Gholamreza Ghavipanjeh

Zahra Nasehi

Mohammad Esmaeil Shahaboddin

Affiliations

Soon will be listed here.

Abstract

Introduction: Diabetic nephropathy is one of the leading causes of end-stage renal disease worldwide. Uncontrolled hyperglycemia and subsequent production of glycation end-products activate the paths which lead to diabetic nephropathy. The aim of this study was to assess the effects of L-lysine on antioxidant capacity, biochemical factors, kidney function, HSP70 level, and the expression of the , , and genes in rats with streptozocin-induced diabetes mellitus.

Methods: Thirty-two male Wistar rats were randomly allocated to four eight-rat groups, namely, a healthy group, a diabetic group treated with vehicle (DM + vehicle), a diabetic group treated with L-lysine (DM + Lys), and a healthy group treated with L-lysine (healthy + Lys). Rats in the DM + Lys and the healthy + Lys groups were treated with L-lysine 0.15%. The levels of fasting blood glucose, insulin, HbA, advanced glycation end-products (AGEs), lipid profile, serum creatinine, blood urea nitrogen, glomerular filtration rate, urine microalbumin, oxidative stress parameters, kidney histology and morphology, and , , and gene expressions were assessed. . An eight-week treatment with L-lysine significantly reduced the levels of fasting blood glucose, AGEs, kidney function parameters, oxidative stress parameters, lipid profile, and the , , and gene expression and significantly increased the levels of serum insulin and tissue HSP70.

Conclusion: Treatment with L-lysine seems to slow down the progression of diabetic nephropathy.

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